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苏州工业园区生物纳米园A4#216
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商品描述
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x30min,1x10min |
| Standardrange | 5-1000mIU/mL |
| Specimen/Volumes | 25µLSerum,plasma |
| Substrate/isotope | TMB,450nm |
| RegulatoryStatus: | EU:CE |
Detailsfor:hCGELISA
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 ThehCGELISAisanenzymeimmunoassayforthequantitativeinvitrodiagnosticmeasurementofintacthumanchorionicgonadotropin(hCG)inserumorplasma.
ChorionicGonadotropin(hCG)isaglycoproteinhormonewhichisnormallyproducedbytheplacentaduringpregnancy.Afterconception,thehCGconcentrationincreasesrapidlytoreachapeakneartheendofthefirsttrimester.Highconcentrationsareobservedthroughoutpregnancy.Afterdelivery,hCGlevelsfallrapidlyandbecomeundetectableafterafewdays.
StructurallyintacthCGmoleculesarecomposedofanalphaandabetasubunitwithamolucularweightof38.4kDa.Thealphasubunitisnearlyidenticaltothealphasubunitsofotherglycoproteinhormones,suchasThyroidStimulatingHormone(TSH),LuteinizingHormone(LH),andFollicleStimulatingHormone(FSH):ThedifferencesinthebetasubunitoftherespectivehormonesaccountfortheirBIOLOGicalspecificityandimmunochemicaldistinctiveness.MonoclonalantibodiesrecognizinguniquesitesonthebetachainofthehCGmoleculeareessentialfordifferentiationbetweenhCGandLH,FSHandTSH.
hCGAssaysareusedfortheearlydetectionofpregnancy.
1.InadditiontotheelevatedhCGlevelsduringpregnancy,highconcentrationsofhCGmaybeassociatedwithneoplasmsoftrophoblasticandnontrophoblasticoriginsuchashydatiformmole,chorionepithelioma,embryonalcellcarcinoma,andmanyothers.
2.HCGiscommonlyelevatedindifferenttesticulartumorsandisthususedasatumorMarkerfortesticulartumorsincombinationwithAFP.ThereisagoodcorrelationbetweenchangesinhCGlevelsandresponsetotherapy.
3.Extragonadalgerm-cellcancersintheabsenceofclinicallyorultrasonographicallydetectabletesticularabnormalitieshavebeeinobservedaswell.Over50%ofpatientswithmalignantinsulinomashaveelevatedhCGlevels:thehormoneisnotdetectedinassociationwithbenignadenomas.EctopicsecretionofhCGalsohavebeenfoundinasmallpercentageofpatientswithadenocarcinomaoftheovary,pancreasandstomach,hepatomas,andislet-cellcarcinomas.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.ChorionicGonadotropin(hCG)isaglycoproteinhormonewhichisnormallyproducedbytheplacentaduringpregnancy.Afterconception,thehCGconcentrationincreasesrapidlytoreachapeakneartheendofthefirsttrimester.Highconcentrationsareobservedthroughoutpregnancy.Afterdelivery,hCGlevelsfallrapidlyandbecomeundetectableafterafewdays.
StructurallyintacthCGmoleculesarecomposedofanalphaandabetasubunitwithamolucularweightof38.4kDa.Thealphasubunitisnearlyidenticaltothealphasubunitsofotherglycoproteinhormones,suchasThyroidStimulatingHormone(TSH),LuteinizingHormone(LH),andFollicleStimulatingHormone(FSH):ThedifferencesinthebetasubunitoftherespectivehormonesaccountfortheirBIOLOGicalspecificityandimmunochemicaldistinctiveness.MonoclonalantibodiesrecognizinguniquesitesonthebetachainofthehCGmoleculeareessentialfordifferentiationbetweenhCGandLH,FSHandTSH.
hCGAssaysareusedfortheearlydetectionofpregnancy.
1.InadditiontotheelevatedhCGlevelsduringpregnancy,highconcentrationsofhCGmaybeassociatedwithneoplasmsoftrophoblasticandnontrophoblasticoriginsuchashydatiformmole,chorionepithelioma,embryonalcellcarcinoma,andmanyothers.
2.HCGiscommonlyelevatedindifferenttesticulartumorsandisthususedasatumorMarkerfortesticulartumorsincombinationwithAFP.ThereisagoodcorrelationbetweenchangesinhCGlevelsandresponsetotherapy.
3.Extragonadalgerm-cellcancersintheabsenceofclinicallyorultrasonographicallydetectabletesticularabnormalitieshavebeeinobservedaswell.Over50%ofpatientswithmalignantinsulinomashaveelevatedhCGlevels:thehormoneisnotdetectedinassociationwithbenignadenomas.EctopicsecretionofhCGalsohavebeenfoundinasmallpercentageofpatientswithadenocarcinomaoftheovary,pancreasandstomach,hepatomas,andislet-cellcarcinomas.
