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商品描述
| Kitsize | 100 |
| Method | RIA(CT) |
| Incubationtime | 1x1h |
| Standardrange | 0.4-50µmol/mL |
| Specimen/Volumes | 25µLserum,plasma |
| Substrate/isotope | 125I<185kBq |
| RegulatoryStatus: | EU:CE |
Detailsfor:BileAcids(Gallensäuren)RIA
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 BileacidsareC24steroidsderivedfromcholesterol.Cholicandcheno-deoxycholicacidsarethetwoprimarybileacidsinman.Inbile,theyareconjugatedwiththeaminoacids,glycineandtaurine,formingthefourconjugatedbileacidswhicharemeasuredbythisassay:glycocholicacid,taurocholicacid,glycochenode-oxycholicacidandtauRochenodeoxy-cholicacid.Theprimarybileacidsundergobacterialdegradationintheintestinetoformthesecondarybileacids,deoxycholic,lithocholicacidsandoxidationproducts.Thesaltsoftheconjugatedbileacidsarepowerfuldetergentswhichaidinintestinalabsorptionoflipids.Theyarealmostentirelyabsorbedbytheintestineandreturnedtotheliverandgallbladderviatheenterohepaticcirculation.Normally,lessthan1%ofthebileacidpoolisfoundinsystemicblood.Ithasbeenknownformanyyearsthattheconcentrationofbileacidsinserumisincreasedinpatientswithliverdiseaseasaresultofthefailureofthediseasedlivertoextractbileacidsefficientlyfromportalblood1.Serumconjugatedbileacidconcentrationshavebeenreportedtoberaisedinmanyformsofstructuralliverdisease.Metabolichepaticdiseasesinvolvingorganicanionsdonotseemtocauseabnormalbileacidconcentrations2.Noincreaseinserumconjugatedbileacids,eveninthepresenceofliverdisease,willbenotedinpatientswithintestinalmalabsorptionsuchasisfoundfollowingilealresectionorby-pass2,3.Ithasbeensuggestedthatbileacidlevelsmaybethesinglemostsensitiveandspecificindicatorofliverdiseasewhereotherchemicalandenzymetestsareoftennormal2,4-9,suggestingapplicationforfollowingrecoveryorpredictingrelapseindiseasessuchashepatitisandformonitoringdrugtoxicity.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
