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蚂蚁淘在线 / 品牌中心 / IBL / IBL/soluble α-Klotho ELISA/JP27998/

IBL/soluble α-Klotho ELISA/JP27998/

价格
面议
货号：JP27998
浏览量：127
品牌：IBL
服务
全国联保
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商品描述
Kitsize12x8
MethodELISA
Incubationtime1x1h,2x30min
Standardrange93.75-2000pg/mL
Specimen/Volumes100µlserum,EDTA-plasma
Substrate/isotopeTMB450nm
RegulatoryStatus:Forresearchuseonly
Detailsfor: solubleα-KlothoELISA
Anovelmessengerofhealthybodies?!

α-Klotho,namedaftertheGreekGoddessofFate,Clotho,whospinsthethreadoflife,wasoriginallycharacterizedasanagingsuppressorgene.OurELISAisperfectlysuitedforthemeasurementoftheproductofthisgene-theα-Klothoprotein.α-Klothoisalsoknownasthemessengerofhealthybodies(FantuzziGFrontImmunol.2014Jul21;5:351).

Adefectinklothogeneexpressioninthemouseresultsinasyndromethatresembleshumanageing,includingashortLifespan,infertility,arteriosclerosis,skinatrophy,osteoporosisandemphysema.Theabsenceofα-Klotholeadstoasubstantiallylowerbonedensitythanusual(Kuro-oMetal.Nature.1997Nov6;390(6655):45-51).

alpha-Klotho deficiency leads to bone mass density loss
Picture:α-Klothodeficiencyleadstobonemassdensitylossasthecomparisonofwildtype(left)andα-Klothoknockoutmice(right)demonstrates(picturekindlyprovidedbyDr.YoichiNabeshima,LaboratoryofMolecularScience,InstituteofBiomedicalResearchandInnovation,FoundationforBiomedicalResearchandInnovation,Kobe,Japan)

Sincethediscoveryofα-Klotho,whichwasdescribedinthepublicationmentionedabove,severalresearchareashaveemergedwhichbenefitfromthedeterminationofα-Klothointermsofgainingvaluableadditionalinformation:

  • Bonemetabolism
  • Agingprocesses
  • Nephrology
  • Immunology,etc.

α-KlothoandFGF23arethemainmediatorsofcalciumandphosphatehomeostasis.Anykindofdisturbanceinthisregard,suchasareducedorincreasedproductionofα-Klotho,leadstometabolicbonedisorders(JohnGBetal.AmJKidneyDis.2011Jul;58(1):127-34).

Itisalreadyknownthatα-Klotholevelsinblooddecreasewithage(YamazakiYetal.BiochemBiophysResCommun.2010Jul30;398(3):513-8).Lowα-klotholevelsareoftenassociatedwithage-relateddiseases.

Theoutcomesofresearchintheareasofbonemetabolismandaging,aswellasthefactthatα-Klothoisproducedexclusivelyinthekidneysandbrain,havepromptedinvestigationsintotheimpactofchangesinα-Klotholevelsinrenaldisease.Studieshaverevealedthatα-klotholevelsaresignificantlydecreasedintheserumalreadyatanearlystageinchronickidneydisease(PavikIetal.NephrolDialTransplant.2013Feb;28(2):352-9).Sincechronickidneydiseasefrequentlyoccurssecondarytoothermedicalconditions,α-KlothoisreceivingincreasingattentionasaMarkeroftheoccurrenceofchronickidneydiseaseinprimarydiseasessuchastype2diabetes(LeeEYetalPLoSOne.2014Aug1;9(8):e102984),wherebythesamplematerialshouldbenoted(seeimagebelow).

alpha Klotho renal function
Figure1:Intype2diabetespatientswithstablerenalfunction,bothplasmaandurineα-Klotholevelsaresignificantlyincreasedcomparedtohealthycontrols.Withdecreasingrenalfunction,shownasalbuminuria,α-Klotholevelsdecreaseinplasmawhileremainingstableinurine.

FurThermore,α-Klothoisgainingincreasingattentionasaplayerinmanyimmunologicalprocesses,whichisreflectedintheincreaseofpublicationsonα-Klotho.

Number of publications on alpha Klotho
Figure2:Thenumberofpublicationsonα-KlothohasbeensteADIlyincreasingsince2005.

Separatecontrolsetavailableonrequest

ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
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