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苏州工业园区生物纳米园A4#216
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商品描述
| Kitsize | 96Tests |
| Method | RIA(CT) |
| Incubationtime | 1x2h(37°C) |
| Standardrange | 0.3-90pg/mL |
| Specimen/Volumes | 50µLSerum |
| Substrate/isotope | 125I<185kBq |
| RegulatoryStatus: | EU:CE |
Detailsfor:FreeTestosteroneRIA(CT)
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 RADIoimmunoassay(CT)forthequantitativedeterminationofFreeTestosterone(FT)inhumanserum.
Freetestosteronediffusesthroughcellmembranesandbindstospecificreceptorproteins(androgenreceptors);theTestosterone-receptorcomplexesactastranscriptionalmodulatorsoncis-regulatoryregionsofmanygenes.
ExcessofAndrogensinwomencauseshirsutismandsignsofvirilization;Testosteronelevelinserumhastobedeterminedbeforeandafterovarianandadrenalstimulationandsupressiontoidentifythesourceofexcessivehormoneproduction.
Primaryandsecondaryhypogonadisminmenresultinclinicalhypoandrogenization,correlatedwiththedegreeofgonadalfailureinTestosteroneproduction.ThedeterminationofserumTestosteronetogetherwiththatofLHallowsthecorrectassessementofthoseconditions.
Thediagnosisoftrueanorchiaalsorequirestodiscriminatethisconditionfromcryptorchidism.UnderprolongedhCGstimulation,Testosteronelevelsremainverylowintrueanorchiawhilecryptorchidtestescanrespondtostimulation.
Androgenresistancesyndromes,duetoXlinkedandrogenreceptorgenedeficiencies,aremadeofvariousdegreesofsexualambiguity.Whatevertheseverityofthephenotypicalabnormalities,serumTestosteroneissystematicallyhighinregardstoelevatedLHserumlevelsintheseconditions.
Testosteroneassaysincludetotaltestosterone(direct,extraction,coatedtubes)andfreetestosteronedeterminations.
TotalTestosteroneinplasmaincludesfreeTestosteroneandTestosteroneboundtoSHBG,albumin,CBG.Themeanpercentageofeachinnormalmenis2.7,32,65and<0.1 respectively.
SolventsbreaktheproteinbindinginextractionassayswhereasblockingagentsreleaseTestosteronefromproteinsindirectassays.Theadvantageofafreetestosteroneassayisthatfreetestosteroneconcentrationsareinequilibriumwithtestosteroneboundtoreceptorsintheorgans.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Freetestosteronediffusesthroughcellmembranesandbindstospecificreceptorproteins(androgenreceptors);theTestosterone-receptorcomplexesactastranscriptionalmodulatorsoncis-regulatoryregionsofmanygenes.
ExcessofAndrogensinwomencauseshirsutismandsignsofvirilization;Testosteronelevelinserumhastobedeterminedbeforeandafterovarianandadrenalstimulationandsupressiontoidentifythesourceofexcessivehormoneproduction.
Primaryandsecondaryhypogonadisminmenresultinclinicalhypoandrogenization,correlatedwiththedegreeofgonadalfailureinTestosteroneproduction.ThedeterminationofserumTestosteronetogetherwiththatofLHallowsthecorrectassessementofthoseconditions.
Thediagnosisoftrueanorchiaalsorequirestodiscriminatethisconditionfromcryptorchidism.UnderprolongedhCGstimulation,Testosteronelevelsremainverylowintrueanorchiawhilecryptorchidtestescanrespondtostimulation.
Androgenresistancesyndromes,duetoXlinkedandrogenreceptorgenedeficiencies,aremadeofvariousdegreesofsexualambiguity.Whatevertheseverityofthephenotypicalabnormalities,serumTestosteroneissystematicallyhighinregardstoelevatedLHserumlevelsintheseconditions.
Testosteroneassaysincludetotaltestosterone(direct,extraction,coatedtubes)andfreetestosteronedeterminations.
TotalTestosteroneinplasmaincludesfreeTestosteroneandTestosteroneboundtoSHBG,albumin,CBG.Themeanpercentageofeachinnormalmenis2.7,32,65and<0.1 respectively.
SolventsbreaktheproteinbindinginextractionassayswhereasblockingagentsreleaseTestosteronefromproteinsindirectassays.Theadvantageofafreetestosteroneassayisthatfreetestosteroneconcentrationsareinequilibriumwithtestosteroneboundtoreceptorsintheorgans.
