ThefastestELISAavailable

IBLpresentsanew,simplifiedadrenocorticotropichormone(ACTH)ELISA,withthefollowingadvantages:

• Assaytimeof2hours(comparedto4hoursbefore)
• Easiercalculationofresults(singleplatereADIngat450nm)
• Highanalyticalsensitivity(LLOD:< 1 pg/mL)
• Widedynamicrange(0-416pg/mL)

ThisnewACTHassaycorrelateswellwithotherELISAsavailableonthemarket.Thisenablesaneasytransitionandsavesthelaboratorytime,effortandmoney.PleasenotethecataloguenumberRE53081ofthenewACTHELISAforordering.

MeasuringplasmaACTH(synonyms:corticotropin,cosyntropin)levelsisextremelyusefulinthediagnosisofbothCushing"ssyndromeandadrenalinsufficiency.ACTHlevelsinthebloodaremeasuredtohelpdetect,diagnoseandmonitorconditionsassociatedwithexcessiveordeficientcortisollevelsinthebody.

AsthelevelofACTHnormallychangesintheoppositedirectiontothelevelofcortisol,weadditionallyrecommendourcortisolassays(forserum,urineand/orsalivameasurement)forthepurposeofdifferentiatingamongthedifferentpituitaryoradrenalconditions.

GeneralinformationontheACTHELISA
ThetestisusefulfordetectingelevatedanddeficientACTHlevels.

Indicationsforuse
PatientswiththefollowingconditionsmayhavehigherthannormallevelsofACTH:

• Addison’sdiseaseorprimaryadrenalinsufficiency
• Congenitaladrenalhyperplasia
• Cushing’ssyndrome
• Cushing’sdisease
• Multipleendocrineneoplasia(MEN),typeI

PatientswiththefollowingconditionsmayhavelowerthannormallevelsofACTH:

• Hypopituitarismand/orsecondaryadrenalinsufficiency
• Adrenaltumor
• Othercortisol-producingtumors

ACTHisa39-amino-acidpolypeptidewithamolecularweightof4540Da.ACTHissecretedbycorticotrophsintheanteriorlobeofthepituitarygland(oradenohypophysis)inresponsetocorticotropin-releasinghormone(CRH)releasedbythehypothalamus.ACTHissynthesizedfrompre-proopiomelanocortin(pre-POMC).Theremovalofthesignalpeptideduringtranslationproducesthe241-amino-acidpolypeptidePOMC,whichundergoesaseriesofpost-translationalmodificationssuchasphosphorylationandglycosylationbeforeitisproteolyticallycleavedbyendopeptidasestoyieldvariouspolypeptidefragmentswithvaryingphysiologicalactivity.

ACTHisanimportantcomponentofthehypothalamic-pituitary-adrenalaxisandisoftenproducedinresponsetoBIOLOGicalstress.Itstimulatesthesecretionofglucocorticoidsteroidhormonesfromtheadrenalcortexcells,especiallyinthezonafasciculataoftheadrenal.ACTHactsbybindingtocellsurfaceACTHreceptors,whicharelocatedprimarilyonadrenocorticalcellsoftheadrenalcortex.

Synonyms:Adrenocorticotropichormone,Corticotropin,Cosyntropin

ThisproductrepresentstherightalternativetodiscontinuedACTHRIA.Pleasecontactusifyoushouldneedanykitfortrialpurposes!Orifyoushouldneedanysupportregardingcomparisonstudies.Wewillbehappytoprovideyouwithexpectedhelp.