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商品描述
| ProductName | Liver-XReceptoralphaisoform |
| Size | 10,000U |
| Description | LiverXreceptors(LXRs)arenuclearreceptorsthatregulatethemetabolismofcholesterolandbileacids(1).TherearetwosubtypesofLXRs,LXRαandLXRβ.LXRβispreferentiallyexpressedinliver,smallintestine,kidneyandspleen(2,3).Incontrast,LXRαexpressionisubiquitous(4).ThegenomicstructureandthepromoterregionsofthetwoLXRgenescontainspecificregulatorysites,whichsuggestthatLXRsmayhavephysiologicalrolesintheimmunesystem(5).Likeothernuclearreceptors,LXRsheterodimerizewithretinoidXreceptor(RXR)forfunction(1).LXRsareactivatedbynaturallyoccurringoxysterolsandregulatetheexpressionoftargetgenes(6-8),includingATPbindingcassettetransporter1(ABC1),ATPbindingcassettetransporter8(ABC8)andcholesterolestertransferprotein(CETP)(9-10).LXRαisthoughttoplayamajorroleinthecontrolofcholesterolcatabolismbystimulatingtheexpressionofcholesterol7alpha-hydroxylase(CYP7A1),theratelimitingenzymeofbileacidsynthesis(11) |
| Applications | LXRhasbeenappliedinDNAandprotein-proteininteractionsassays |
| Source | E.coli |
| FusionTag | 6XHis |
| PurificationMethod | FPLC |
| UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein.20unitsaresufficientforagel-mobilityshiftassayand100unitsaresufficientforaprotein-proteininteractionassay |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 10062 |
| Accession# | NM_005693 |
| GeneName | NR1H3 |
| GeneSynonyms | NR1H3;LXRAandRLD-1 |
| MW | 53.7kDa |
| ProteinSequence | SLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAA EPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGF FRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKR QEEEQAHATSLPPRRSSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMA PDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLE TSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIA ISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVH SEQVFALRLQDKKLPPLLSEIWDVHE |
| StorageBuffer | 20mMTris-HCl,pH8.0,250mMNaCl,50%Glycerol |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.Peetetal.,(1998)Curr.Opin.Gent.Dev.8,571-575 2.Willyetal.,(1995)GenesDev.9,1033-1045 3.Apfeletal.,(1994)Mol.Cell.Biol.14,7025-7035 4.Songetal.,(1994)Proc.Natl.Acad.Sci.91,10809-10813 5.Albertietal.,(2000)Gene243,93-103 6.Janowskietal.,(1996)Nature383,728-731 7.Lehmannetal.,(1997)J.Biol.Chem.272,3137-3140 8.Janowskietal.,(1999)Proc.Natl.Acad.Sci.96,266-271 9.Luoetal.,(2000)J.Clin.Invest.105,513-520 10.Venkateswaranetal.,(2000)J.Biol.Chem.275,14700-14707 11.Peetetal.,(1998)Cell93,693-704 |
