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蚂蚁淘在线 / 品牌中心 / Excellgen / Excellgen/Thyroid Hormone Receptor beta 1 isoform/RP-142/10,000 U

Excellgen/Thyroid Hormone Receptor beta 1 isoform/RP-142/10,000 U

价格
￥4400.00
货号：RP-142
浏览量：127
品牌：Excellgen
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商品描述
ProductNameThyroidHormoneReceptorbeta1isoform
Size10,000U
DescriptionNuclearreceptorsformthelargestknownfamilyoftranscriptionfactorsandhaveacrucialroleinnearlyallaspectsofvertebratedevelopmentandadultphysiologybytransducingtheeffectsofhormonesintotranscriptionalresponses(1).Thefamilyisdefinedbytwodomains:(a)thecentral,highlyconserved,DNA-bindingdomain(DBD)ofapproximately66aminoacids,and(b)theC-terminal,structurallyconserved,ligand-bindingdomain(LBD)ofapproximately250aminoacids(2,3).Theamino-terminalregionsareleastconservedamongnuclearreceptorsequences.ThisdomainishighlydivergentbetweenTRαandTRβisoforms,whichsuggestsdifferentialrolesintranscriptionalregulation.Inaddition,alternativesplicingoftheTRαgenegeneratestwoisoforms,TRα1andTRα2withcompletelydifferentamino-terminaldomains(4).UnligandedTRinhibitstheformationofafunctionalpre-initiationcomplex,throughdirectinteractionwithTBPandtranscriptionfactorIIB(5-7).Inaddition,intheabsenceofligand,TRhasbeenshowntorepresstranscriptionthroughrecruitmentofacorepressorcomplex,whichalsoincludesSin3Aandhistonedeacetylase(8,9).Ligandbindingreleasesthecorepressorcomplexandrecruitsacoactivatorcomplexthatincludesmultiplehistoneacetyltransferases,includingasteroidreceptorfamilycoactivator,p300/CREB-bindingprotein–associatedfactor(PCAF),andCREBbindingprotein(CBP)(10-14).
Applications
  • reconstitutedinvitrotranscriptionassays
  • protein-proteininteractionsassays
  • chromatinremodelingassays
SourceE.coli
FusionTagHistag
PurificationMethodFPLC
UnitDefinition(Activity)1unitequalsto1nanogramofpurifiedprotein.1unitissufficientforagelmobilityshiftassayina20µlreaction;100unitsaresufficientforprotein-proteininteractionassays.
Purity

~95%asdeterminedbySDS-PAGE

GeneID6257
Accession#NM_021976
GeneName

retinoidXreceptor,beta

GeneSymbolRXRB
GeneSynonymsNR2B2;DAUDI6;RCoR-1;H-2RIIBP
MW58.6kDa.
ProteinSequenceMTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
StorageBuffer20mMTris-HCl,pH8.0,250mMNaCl,1mMDTT,50%Glycerol
Storage-20to-80°C.
Shipping4°Cordryice
References

1.Mangelsdorf,D.J.,etal.,(1995)Cell83,835–839
2.Glass,C.K.(1994)Endocrinol.Rev.15,391–407
3.Moras,D.,etal.,(1998)Curr.Opin.CellBiol.10,384-391
4.KliewerS.A.,etal.,(1992)Nature355,446–449
5.GlassC.K.,etal.,(1989)Cell59,697-708
6.NagyL.,etal.,(1997)Cell89,373-380
7.Heinzel,T.,etal.,(1997)Nature387,43-48
8.Onate,S.A.,etal.,(1995)Science270,1354-1357
9.Kamei,Y.,etal.,(1996)Cell85,403-414
10.Blanco,J.C.,etal.,(1998)GenesDev.12,1638-1651
11.Fondell,J.D.,etal.,(1996)Proc.Natl.Acad.Sci.USA93,8329-8333
12.Wolffe,A.,etal.,(1997)GenesCells2,291-302

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