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商品描述
| ProductName | MAD(MAXdimerizationprotein1,MXD1) |
| Size | 10,000U |
| Description | MAXdimerizationproteinbelongstoasubfamilyofMAX-interactingproteins.ThisproteincompeteswithMYCforbindingtoMAXtoformasequence-specificDNA-bindingcomplex,actingasatranscriptionalrepressor(whileMYCappearstofunctionasanactivator)andisacandidatetumorsuppressor.BothMycandMad,aswellasthemorerecentlydescribedMntandMgaproteins,formheterodimerswithMax,permittingbindingtospecificDNAsequences.TheseDNA-boundheterodimersrecruitcoactivatororcorepressorcomplexesthatgeneratealterationsinchromatinstructure,whichinturnmodulatetranscription(1).Thewild-typec-Mycandc-Myc/MadBRproteinshaveindistinguishableBIOLOGicalactivityandtargetgenerecognitioninvivo(2) |
| Applications | DNAbinding,proliferation,differentiation,andapoptosisresearchstudies |
| Source | E.coli |
| FusionTag | Flag |
| PurificationMethod | FPLC |
| UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 4084 |
| Accession# | NM_002357 |
| GeneName | MAXdimerizationprotein1 |
| GeneSymbol | MXD1 |
| GeneSynonyms | MAD;MAD1;BHLHC58 |
| MW | 26.6kDa |
| ProteinSequence | MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRST HNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQID QLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSS SSVSDSDERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL |
| StorageBuffer | 20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.Grandori,C.,etal.Annu.Rev.CellDev.Biol.16,653-699(2000) 2.Nikiforov,M.A.,etal.J.Biol.Chem.278(13),11094-11099(2003) |
