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商品描述
| ProductName | FRA-1 |
| Size | 5,000U |
| Description | Thefos-relatedantigen1(Fra-1,orFosL1:Fos-likeantigen1)isamemberoftheFosonco-proteinfamilyandacomponentofAP-1transcriptionfactor(1).Similartoothermembersofthefamily,Fra-1containsaleucinezipperdomainandahighlyconservedC-terminalregion(2).TranscriptionofFra-1geneisregulatedbymultiplecis-elementsand12-O-tetradecanoylphorbol-13-acetate(TPA)(3).Fra-1expressionisassociatedwithproliferationandinvasivenessofbreastcancercellsandothercancercells(4,5) |
| Applications |
|
| Source | Baculovirus-insectcell |
| FusionTag | 6XHis |
| PurificationMethod | FPLC |
| UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein.20-200ngissufficientforaninvitrotranscriptionassayand100ngissufficientforaprotein-proteininteractionassay |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 8061 |
| Accession# | NM_005438 |
| GeneName | FOS-likeantigen1 |
| GeneSymbol | FOSL1 |
| GeneSynonyms | FRA;FRA1;fra-1 |
| MW | 31.2kDa |
| ProteinSequence | MFRDFGEPGPSSGNGGGYGGPAQPPAAAQAAQQKFHLVPSINTMSGSQELQWMVQPHFLG PSSYPRPLTYPQYSPPQPRPGVIRALGPPPGVRRRPCEQISPEEEERRRVRRERNKLAAA KCRNRRKELTDFLQAETDKLEDEKSGLQREIEELQKQKERLELVLEAHRPICKIPEGAKE GDTGSTSGTSSPPAPCRPVPCISLSPGPVLEPEALHTPTLMTTPSLTPFTPSLVFTYPST PEPCASAHRKSSSSSGDPSSDPLGSPTLLAL |
| StorageBuffer | 20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.CohenDR,etal.,(1989)GenesDev.Feb;3(2):173-84. 2.MatsuiM,etal.,(1990)Oncogene.Mar;5(3):249-55. 3.ADIseshaiahP,etal.,(2003)JBiolChem.Nov28;278(48):47423-33 4.BelguiseK,etal.,(2005)Oncogene.Feb17;24(8):1434-44. 5.WangHL,etal.,(2002)IntJCancer.Oct1;101(4):301-10. |
