快报
欢迎光临蚂蚁淘在线！ 请登录 免费注册
商品
品牌
文章
热门搜索：
快报
品牌首页 品牌新闻 品牌简介 产品中心 品牌咨询 联系我们
品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
蚂蚁淘在线 / 品牌中心 / Excellgen / Excellgen/Lelch-like ECH-associated protein 1, KEAP1/RP-71/100

Excellgen/Lelch-like ECH-associated protein 1, KEAP1/RP-71/100

价格
￥5000.00
货号：RP-71
浏览量：127
品牌：Excellgen
服务
全国联保
正品保证
正规发票
签订合同
商品描述
ProductNameLelch-likeECH-associatedprotein1,KEAP1
Size100µg
Description

Keap1hasfourdiscreteproteindomains.TheN-terminalBroadcomplex,TramtrackandBric-à-Brac(BTB)domaincontainstheCys151residue,whichoneoftheimportantcysteinesinstresssensing.Theinterveningregion(IVR)domaincontainstwocriticalcysteineresidues,Cys273andCys288,whichareasecondgroupofcysteinesimportantforstresssensing.Adoubleglycinerepeat(DGR)andC-terminalregion(CTR)domainscollaboratetoformaβ-propellerstructure,whichiswhereKeap1interactswithNrf2.

Keap1hasbeenshowntointeractwithNrf2,amasterregulatoroftheantioxidantresponse,whichisimportantfortheameliorationofoxidativestress.Underquiescentconditions,Nrf2isanchoredinthecytoplasmthroughbindingtoKeap1,which,inturn,facilitatestheubiquitinationandsubsequentproteolysisofNrf2.SuchsequestrationandfurtherdegradationofNrf2inthecytoplasmaremechanismsfortherepressiveeffectsofKeap1onNrf2.

BecauseNrf2activationleadstoacoordinatedantioxidantandanti-inflammatoryresponse,andKeap1repressesNrf2activation,Keap1hasbecomeaveryattractivedrugtarget.Syntheticoleanetriterpenoidcompounds,knownasantioxidantinflammationmodulators(AIMs)havebeenshowntoblockKeap1-dependentNrf2ubiquitinationandleADIngtothestABIlizationandnucleartranslocationofNrf2andsubsequentinductionofNrf2targetgenes.

Sourcebaculovirus/sf9cells
FusionTag6XHis
PurificationMethodFPLC
Purity

~95%asdeterminedbySDS-PAGE

GeneID9817
Accession#NM_000546
GeneName

kelch-likeECH-associatedprotein1

GeneSymbol

KEAP1

GeneSynonymsINrf2;KLHL19
MW69.6kDa
ProteinSequence

1MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
61KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
121EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
181PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
241CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
301LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
361PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
421IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
481TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
541TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
601RSGVGVAVTMEPCRKQIDQQNCTC

StorageBuffer20mMTris-Cl(pH8.0),50%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA
Storage-20to-80°C.
Shipping4°Cordryice
Excellgen蛋白表达产品名称-目录 ＃价钱293Expresso™转染试剂EG-1089$ 98.00定制抗体生产和免疫测定开发EG-36从培养基中纯化IgEEG-1076-1$ 750.00MembraneExpress TM功能膜蛋白的病毒样颗粒EG-1038蛋白质表达和纯化服务EG-1076-8$ 1,500.00小规模表达测试和纯化方法开发EG-1081-3$ 1,250.00使用HEK 293细胞的瞬时蛋白质生产EG-1080$ 2,900.00  $ 1,950.00-$ 950.00使用细菌表达系统进行蛋白表达和纯化EG-1076$ 2,170.00使用杆状病毒表达系统进行蛋白质表达和纯化EG-1078$ 4,500.00使用Akta FPLC系统的定制蛋白质纯化服务EG-1082$ 1,000.00使用稳定的哺乳动物细胞系表达蛋白质EG-1081$ 9,500.00