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商品描述
| Description | |
|---|---|
| CatalogueNumber | AB1772 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-SEROtoninTransporterAntibody |
| ProductInformation | |
|---|---|
| Format | Serum |
| Presentation | Liquid,nopreservatives. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforuptooneyear.Avoidrepeatedfreeze/thawcycles. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | Syntheticpeptidefromthecarboxy-terminusoftheclonedratserotonintransporter. |
| Host | GuineaPig |
| Specificity | SerotoninTransporter.Theantiserumhasbeentestedontissuesectionsfromthecentralnervoussystem.ThestainingpatternobtainedwiththeAB1772correspondstothepatterndescribedusingantiserumtoserotoninitself.Theserotonintransporterimmunoreactivitycorrespondstowhathasbeendescribedusingotherantibodiestotheserotonintransporter.Preabsorptionoftheantiserumwiththeimmunogenpeptidecompletelyabolishestheimmunostaining. |
| SpeciesReactivity |
|
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesanintegralmembraneproteinthattransportstheneurotransmitterserotoninfromsynapticspacesintopresynapticneurons.Theencodedproteinterminatestheactionofserotoninandrecyclesitinasodium-dependentmanner.Thisproteinisatargetofpsychomotorstimulants,suchasamphetaminesandcocaine,andisamemberofthesodium:neurotransmittersymporterfamily.Arepeatlengthpolymorphisminthepromoterofthisgenehasbeenshowntoaffecttherateofserotoninuptakeandmayplayaroleinsuddeninfantdeathsyndrome,aggressivebehaviorinAlzheimerdiseasepatients,anddepression-susceptibilityinpeopleexperiencingemotionaltrauma. |
| GeneSymbol |
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P31645#Terminatestheactionofserotoninbyitshighaffinitysodium-dependentreuptakeintopresynapticterminals. SIZE:630aminoacids;70325Da SUBUNIT:InteractswithTGFB1I1. SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein. SIMILARITY:SwissProt:P31645##Belongstothesodium:neurotransmittersymporter(SNF)family. MISCELLANEOUS:Thisproteinisthetargetofpsychomotorstimulantssuchasamphetaminesorcocaine. |
| PhysicochemicalInformation |
|---|
| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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