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蚂蚁淘在线 / 品牌中心 / Millipore / Millipore/553510 | RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem/553510/
商品描述
| Description | |
|---|---|
| Overview | Acell-permeablesulfonamido-benzamide-basedallostericregulatorthatstimulatesDNAbindingandrecombinaseactivitiesofhRAD51bylockinghRAD51inanactiveconformationwithoutaffectingitsactivesiteATPhydrolysis.AlthoughRS-1enhanceshRAD51filamentformationonssDNAwithorwithoutthecofactorNTP,activefilamentsandrecombinaseactivityareonlyinducedinthepresenceofATPorAMP-PNP,butnotwithADPornocofactors.ShowntopromoteresistanceofprimaryhumanneonataldermalfibroblaststoCisplatin-(Cat.No.232120)induceddeathinadose-dependentmanner.RS-1isinactivetowardrelatedDNAstrandexchangeproteinsscRAD5andscDMC1ofyeastoriginorE.coliRedA.ThisHDR(homology-directedrepair)enhancer,isshowntosignificantlyincreasebothCas9&TALEN-mediatedknock-inefficiencies. |
| CatalogueNumber | 553510 |
| BrandFamily | Calbiochem® |
| Synonyms | 3-((Benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)-benzamide,RS-1 |
| ProductInformation | |
|---|---|
| CASnumber | 312756-74-4 |
| Form | Lightbeigesolid |
| HillFormula | C₂₀H₁₆Br₂N₂O₃S |
| Chemicalformula | C₂₀H₁₆Br₂N₂O₃S |
| StructureformulaImage |  |
| StorageandShippingInformation | |
|---|---|
| ShipCode | AmbientTemperatureOnly |
| Toxicity | StandardHandling |
| Storage | +2°Cto+8°C |
| ProtectfromLight | Protectfromlight |
| Donotfreeze | Oktofreeze |
| SpecialInstructions | Followingreconstitution,aliquotandfreeze(-20°C).Stocksolutionsarestableforup3monthsat-20°C. |
| Applications |
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| BIOLOGicalInformation | |
|---|---|
| Purity | ≥95%byHPLC |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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