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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/(-)-Cytisine/25 mg/C-130-25 mg

Discovery Antibodies/(-)-Cytisine/25 mg/C-130-25 mg

价格

￥1260.00

货号：C-130-25mg

浏览量：127

品牌：Discovery

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商品描述

Cat#:C-130

AlternativeNameBaphitoxine,Sophorine

LyophilizedPowder

BioassayTested

SourceSynthetic

MW:190.2

Purity:>95%

Effectiveconcentration40nM-1μM.

Structure-+

Chemicalname(1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one.

MolecularformulaC₁₁H₁₄N₂O.

CASNo.:485-35-8.

Activity(-)-CytisineisapotentandselectiveagoNISTofneuronalnAChR.Itactsasapartialagonistatβ2-containingnAChR^1,2.

References-Activity-+

ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.

SolubilityAnyaqueousbuffer(upto100mMstock).Centrifugeallproductpreparationsbeforeuse(10000xg5min).

StorageofsolutionsUptooneweekat4°Corsixmonthsat-20°C.

Ourbioassay-+

References-Scientificbackground

1.Banko,P.C. etal. (2002) J.Chem.Ecol. 28, 1393.

2.Albuquerque,E.X. etal. (2009) Physiol.Rev. 89, 73.

3.Luetje,C.W.andPatrick,J. (1991) J.Neurosci. 11, 837.

4.Chavez-Noriega,L.E. etal. (1997) J.Pharmacol.Exp.Ther. 280, 346.

5.Papke,R.L.andHeinemann,S.F. (1994) Mol.Pharmacol. 45, 142.

6.Mineur,Y.S. etal. (2007) Neuropharmacology 52, 1256.

7.Reavill,C. etal. (1990) Neuropharmacology 29, 619.

Scientificbackground-+

TargetnAChR

LyophilizedPowder

Clickheretoreceivea10mgfreetrialsample!

Lastupdate:24/09/2019

(-)-Cytisine(#C-130) isahighlypure,synthetic,andbiologicallyactivecompound.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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