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商品描述
LyophilizedPowderLyophilizedPowder
Thisproductisfreezedried.Allwatermoleculeshavebeenremoved.
BioassayTestedBioassayTested
Everylotistried&testedinarelevantBIOLOGicalassay.
OurBioassay
SourceSynthetic
MW:376.1
Purity:>99.9%
FormLyophilizedpowder.
Effectiveconcentration40nM-10µM.
ChemicalnameN,N"-(1,4-phenylenedi-2,1-ethanediyl)bis-2-propanesulfonamide.
MolecularformulaC16H28N2O4S2.
CASNo.:380607-77-2.
ActivityCMPDAisaselectiveAMPAreceptoragoNIST(allostericpotentiator).EC50 =45.4and63.4nMatGluR2iandGluR2orespectively,inacalciuminfluxscreeningassay1.
- Timm,D.E. etal.(2011) Mol.Pharmacol. 80, 267.
ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
Solubility100mMinDMSO.Centrifugeallproductpreparationsbeforeuse(10000xgfor1min).
StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.
References-Scientificbackground
- 1.Suppiramaniam,V. etal.(2001) Synapse 40, 154.
- 2.Timm,D.E. etal.(2011) Mol.Pharmacol. 80, 267.
- CMPDAisanovelpositiveallostericmodulatorofAMPAreceptors.SuchallostericmodulatorsactbyenhancingnormalAMPAreceptoractivitytomimiclong-termpotentiationandprolongopen-channeltimebyslowingorpreventingchannelclosure.Slowingtheterminationofaglutamate-evokedresponseenhancesexcitatorypostsynapticpotentialsbyincreasingionfluxthroughAMPAreceptorchannels1.CMPDAmodulatesAMPAsubunitGluA2receptor(GluR2)anditsdesensitizationanddeactivation(EC50 =45.4and63.4nMatGluR2iandGluR2orespectively,inacalciuminfluxscreeningassayofGluA2iandGluA2oreceptorsexpressedinHEK293cells).Thiscompoundbindsatthemodulatorbindingpocketlocatedattheinterdimerinterfaceandtheclamshellhinges2.ThispocketisapowerfultargetfordrugdiscoveryofcompoundsthatmodulateAMPAreceptorsandisapossiblesiteofactionforendogenousmetabolites.
TargetAMPAreceptors
LyophilizedPowder
Clickheretoreceivea5mgfreetrialsample!
Lastupdate:24/09/2019
CMPDA(#C-215) isahighlypure,synthetic,andbiologicallyactivecompound.
Forresearchpurposesonly,notforhumanuse
Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。
