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商品描述
AlternativeName(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid
LyophilizedPowderLyophilizedPowder
Thisproductisfreezedried.Allwatermoleculeshavebeenremoved.
BioassayTestedBioassayTested
Everylotistried&testedinarelevantBIOLOGicalassay.
OurBioassay
SourceSynthetic
MW:186.17
Purity:>99%(HPLC)
Effectiveconcentration0.01-10µM.
Chemicalname(2S)-2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoicacid.
MolecularformulaC7H10N2O4.
CASNo.:83643-88-3.
PubChemCID158397
ActivityAnactiveenantiomerofAMPA(EC50 =3.5 μM)1.
- Falch,E. etal. (1998)J.Med.Chem. 41, 2513.
ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.
Solubility100mMinH2O.Centrifugeallproductsbeforereconstitution(10000xg5min).
StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.Itisrecommendedtoaliquotreconstitutedstocksolutions.
References-Scientificbackground
- 1.Falch,E. etal. (1998)J.Med.Chem. 41, 2513.
- 2.Guntupalli,S.etal.(2016)Neural.Plast. 2016,3204519.
(S)-AMPAenantiomerisasyntheticAMPAreceptoragoNIST.Thecompoundmimicstheeffectsoftheglutamateneurotransmitter1.
IonotropicglutamateAMPAreceptors(AMPARs)aretheprimaryreceptorsthatmediatefastexcitatorysynaptictransmissioninthemammalianbrain.Themajorityofthistransmissioninthemammaliancentralnervoussystemismediatedbythereleaseofglutamatefromthepresynapticterminalanditsbindingtoglutamatereceptorsonthepostsynapticmembrane2.
TargetAMPAreceptors
LyophilizedPowder
Clickheretoreceivea1mgfreetrialsample!
Lastupdate:13/10/2019
(S)-AMPA(#A-267) isahighlypure,synthetic,andbiologicallyactivecompound.
Forresearchpurposesonly,notforhumanuse
Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。
