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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-IP3 Receptor-1 (ITPR1) Antibody/50 µl/ACC-019-50 µl

Discovery Antibodies/Anti-IP3 Receptor-1 (ITPR1) Antibody/50 µl/ACC-019-50 µl

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￥7340.00

货号：ACC-019-50µl

浏览量：103

品牌：Discovery

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商品描述

Cat#:ACC-019

AlternativeNameInositol1,4,5-trisphosphatereceptortype1, IP3R1, InsP3R1

LyophilizedPowder

AntigenIncl.

Type:Polyclonal

Host:Rabbit

Reactivity:h,m,r

Immunogen-+

Accession(Uniprot)NumberP29994

GeneID25262

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyHuman,mouse-identical.

RRIDAB_2039923.

PurityIgGfractionpurifiedonimmobilizedProteinA.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution25µl,50μlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.

Antibodyconcentrationafterreconstitution0.3mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).

NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.

Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).

Negativecontrolantigenstorageafterreconstitution-20°C.

PreadsorptionControl1μgpeptideper1μgantibody.

StandardqualitycontrolofeachlotWesternblotanalysis.

Applications:ic,if,ih,ip,wb

Mayalsoworkin:ifc*

Westernblot-+

Immunoprecipitation-+

Immunohistochemistry-+

References

1.Blondel,O.etal.(1993)J.Biol.Chem.268,11356.

2.V"arnai,P.etal.(2005)Proc.Natl.Acad.Sci.U.S.A.102,7859.

3.Cai,W.etal.(2004)J.Biol.Chem.279,23691.

Scientificbackground-+

LyophilizedPowderNegativeControlAntigenIncluded

Clickheretoreceivea25µlfreetrialsample!

Image&Title:

Anti-IP3 Receptor-1 (ITPR1) Antibody
ExpressionofIP₃receptor1inTAmusclesections.Immunohistochemicalstainingofmousemusclesectionsusing Anti-IP₃ Receptor-1 (ITPR1) Antibody(#ACC-019).IP3R1staining(green)isdetectedattheneuromuscularjunction(upperpanel).StainingisalmostcompletelyerADIcateduponsiRNAtreatment(middlepanel).IP3R1specificstainingisshownuponscrambledRNA(ctRNA)treatment(lowerpanel).AdaptedfromZhu,H. etal. (2011) J.Neurosci. 31, 15269.withpermissionoftheSocietyforNeuroscience.

Lastupdate:10/11/2019

Anti-IP₃Receptor-1(ITPR1)Antibody(#ACC-019)isahighlyspecificantibodydirectedagainstanepitopeoftheratprotein.Theantibodycanbeusedinwesternblot,immunohistochemistry,andimmunocytochemistryapplications.IthasbeendesignedtorecognizeIP3R1fromhuman,rat,andmousesamples.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-IP3 Receptor-1 (ITPR1) Antibody/50 µl/ACC-019-50 µl

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