Catalogue number	crb2115052e
Antibody	Alexa Fluor® 488 Anti-NR3B antibody
Antigen Peptide	KLH conjugated synthetic peptide crb1200339e
Protein ID	UniProtKB - P11474
Cross-Reactivity	Rat, mouse
Host Species	Anti-Rabbit
Antibody Type	Polyclonal
Concentration	0.56mg/mL
Validation	ELISA
Target	NR3B
Disease Area	Neurodegenerative
Family	Glutamate gated ion channel famility
Specificity	Protein
Storage	Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°
References	Ciabarra, A., Sullivan, J., Gahn, L., Pecht, G., Heinemann, S. and Sevarino, K. (1995). Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. J Neurosci, 15(10), 6498-6508. PMID: 7472412 Low, C. and Wee, K. (2010). New Insights into the Not-So-New NR3 Subunits of N-Methyl-D-aspartate Receptor: Localization, Structure, and Function. Mol Pharmacol, 78(1), 1-11. PMID: 20363861 Prithviraj, R. and Inglis, F. (2008). Expression of the N-methyl-d-aspartate receptor subunit NR3B regulates dendrite morphogenesis in spinal motor neurons. Neuroscience, 155(1), 145-153. PMID: 18541382

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。