Catalogue numbercrb2005226AntibodyAnti-phospho-FoxO1 (pS218) antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200468eProtein IDUniProtKB - Q12778Cross-ReactivityHuman, rat, mouse. May also recognise the equivalent serine in FoxO3/4/6 Host Species Anti-RabbitAntibody TypePolyclonalConcentration0.5 mg/mlValidationWB (1:500), ELISA (1:1000), IHC (1:100)Targetphosphorylated FoxO1 (pS218)Disease AreaCancer, Cell signalling, MetabolismSpecificityProtein Storage The product should be stored at -20°C for for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. CitationsRiddell, M., Nakayama, A., Hikita, T., Mirzapourshafiyi, F., Kawamura, T., Pasha, A., Li, M., Masuzawa, M., Looso, M., Steinbacher, T., Ebnet, K., Potente, M., Hirose, T., Ohno, S., Fleming, I., Gattenlöhner, S., Aung, P., Phung, T., Yamasaki, O., Yanagi, T., Umemura, H. and Nakayama, M. (2018). aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability. Nature Comm, 9(1). PMID: 30559384References

Wilhelm, K., Happel, K., Eelen, G., Schoors, S., Oellerich, M., Lim, R., Zimmermann, B., Aspalter, I., Franco, C., Boettger, T., Braun, T., Fruttiger, M., Rajewsky, K., Keller, C., Brüning, J., Gerhardt, H., Carmeliet, P. and Potente, M. (2016). FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature, 529(7585), 216-220. PMID: 26735015

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。