Catalogue numbercrb2005271AntibodyAnti-SUMO1 antibodyAntigen PeptideProteinAliasesSmall Ubiquitin-like Modifier 1Cross-ReactivityArabidopsis, Rice, wheat, tomato, barleyHost Species RabbitAntibody TypePolyclonalValidation1:2000 (WB)TargetArabidopsis SUMO1SpecificityProtein Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. Citations

Orosa et al.Nat Commun.2018 Dec 5;9(1):5185. doi: 10.1038/s41467-018-07696-8.PMID:30518761

ReferencesPMID: 23746843,PMID: 24726323 Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。