Catalogue numbercrb2005007AntibodyAnti-mGluR2 Antibody Antigen PeptideKLH conjugated synthetic peptide crb1200279eProtein IDUniProtKB - Q14416AliasesGRM2, GPRC1B, MGLUR2, GLUR2, mGlu2, glutamate metabotropic receptor 2, mGluR2Cross-ReactivityRat, MouseHost Species RabbitAntibody TypePolyclonalLabelUnconjugatedConcentration1mg/mlValidationWB/ ELISATargetmGluR2Disease AreaNeurodegenerative diseasesFamilyG-protein coupled receptor 3 familySpecificityProteinStorage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.References

Wood, C., Wafford, K., McCarthy, A., Hewes, N., Shanks, E., Lodge, D. and Robinson, E. (2018). Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression. Neuropharmacology, 140, 246-259. PMID: 30005976

Yang, H., Zhang, H., Bi, G., He, Y., Gao, J. and Xi, Z. (2017). Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. Cell Rep, 20(2), 319-332. PMID: 28700935

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。