Catalogue numbercrb2005228AntibodyAnti-OTULIN antibodyAntigen PeptideProteinProtein IDUniProtKB-Q96BN8AliasesUbiquitin thioesterase otulin, FAM105BCross-ReactivityHumanHost Species RabbitAntibody TypePolyclonalConcentrationserumValidation1:1000 (WB), 1:1000 (ELISA)TargetOTULINSpecificityProtein Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References

Damgaard, R., Walker, J., Marco-Casanova, P., Morgan, N., Titheradge, H., Elliott, P., McHale, D., Maher, E., McKenzie, A. and Komander, D. (2016). The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell, 166(5), 1215-1230.e20. PMID: 27523608

Elliott, P. and Komander, D. (2015). Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN. FEBS J, 283(1), 39-53. PMID: 26503766

Weber, A., Elliott, P., Pinto-Fernandez, A., Bonham, S., Kessler, B., Komander, D., El Oualid, F. and Krappmann, D. (2017). A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN. Cell Chem Biol, 24(10), 1299-1313.e7. PMID: 28919039

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。