Catalogue number	crb2115050e
Antibody	Alexa Fluor® 488 Anti-KA1 antibody
Antigen Peptide	KLH conjugated synthetic peptide crb1200337e
Protein ID	UniProtKB - Q01812
Aliases	Glutamate receptor ionotropic, kainate 4, Grik4, GluK4, KA1, Glutamate receptor KA-1
Cross-Reactivity	Mouse, Rat
Host Species	Anti-Rabbit
Antibody Type	Polyclonal
Label	Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm
Concentration	0.19mg/mL
Validation	ELISA
Target	KA1
Family	Glutamate-gated ionic channel family
Specificity	Protein
Storage	Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C.
References	Gauthier, S., Van Haaften, E., Cherbas, L., Cherbas, P. and Hewes, R. (2012). Cryptocephal, the Drosophila melanogaster ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2. PLoS Genet, 8(8), e1002883. PMID: 22912598 Hewes RS1, Schaefer AM, Taghert PH. (2000). The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila. Genetics. 155(4), 1711-1723. PMID: 10924469

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。