Catalogue number	crb2115025e
Antibody	Alexa Fluor® 488 Anti-ERK1/2 antibody (Rabbit Polyclonal IgG)
Antigen Peptide	KLH conjugated synthetic peptide crb1200306e
Protein ID	UniProtKB - P27361
Aliases	Extracellular Signal-Related Kinase 1, ERK1, ERK-1, ERK2, ERK-2, Mitogen-Activated Protein Kinase 3, MAP Kinase 3, MAPK 3.
Cross-Reactivity	Human, rat, mouse
Host Species	Anti-Rabbit
Antibody Type	Polyclonal
Label	Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm
Concentration	0.67mg/ml
Validation	ELISA
Target	ERK1/2
Family	Mitogen-activated protein (MAP) kinases family
Specificity	ERK1 and ERK2
Storage	Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C
References	Cook, S., Stuart, K., Gilley, R. and Sale, M. (2017). Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling. FEBS J, 284(24), 4177-4195. PMID: 28548464 Zou, J., Lei, T., Guo, P., Yu, J., Xu, Q., Luo, Y., Ke, R. and Huang, D. (2018). Mechanisms shaping the role of ERK1/2 in cellular senescence (Review). Mol Med Rep, 19(2), 759–770. PMID: 30535440

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。