Cataloguenumbercrb2005038AntibodyAnti-RAMP1antibodyAntigenPeptideKLHconjugatedsyntheticpeptidecrb120320eProteinIDUniProtKB-O60894Cross-ReactivityHuman,Rat,MouseHostSpeciesRabbitAntibodyTypePolyclonalConcentration0.4mg/mlValidation1:200(WB),1:100,1:500,1:1000(ELISA),1:500(IF)TargetRAMP1FamilyRAMPfamilyStorageThismaterialissuppliedinPBScontaining0.01%sodiumazideand1%trehalose.Theproductshouldbestoredat+4°Cforshorttermstorageand-20°Cforlongtermstorage.Avoidrepeatedfreeze/thawcycles.References

Li,M.,Wetzel-Strong,S.,Hua,X.,Tilley,S.,Oswald,E.,Krummel,M.andCaron,K.(2014).DeficiencyofRAMP1AttenuatesAntigen-InducedAirwayHyperresponsivenessinMice.PLoSONE,9(7),e102356.PMID:25010197

Suekane,A.,Saito,Y.,Nakahata,S.,Ichikawa,T.,Ogoh,H.,Tsujikawa,K.andMorishita,K.(2019).CGRP-CRLR/RAMP1signalisimportantforstress-inducedhematopoiesis.SciRep,9(1).PMID:30674976

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。