Cataloguenumbercrb2005253AntibodyAnti-crcantibodyAntigenPeptideRecombinantproteinProteinIDUniProtKB-Q9VID3_DROMEAliasesCryptocephal,dATF4Cross-ReactivityUniProtKB-Q9VID3_DROMEHostSpeciesRabbitAntibodyTypePolyclonalConcentrationserumValidationWB(1:1000),ELISA(1:1000)TargetCryptocephalDiseaseAreaCellstresssignalling,Integratedstressresponse,Unfoldedproteinresponse,Developmentalsignalling,Coffin-LowrySyndrome,LeukoencephalopathyWithVanishingWhiteMatter,InflammatoryboweldiseaseFamilybasic-leucinezippertranscriptionfactors,CREB/ATFfamilyofbasic-leucinezippertranscriptionfactorsSpecificityProteinStorageTheproductshouldbestoredat-20°Cforforshorttermstorageandlongtermstorage.Avoidrepeatedfreeze/thawcycles.CitationsMalzerE.,DominicusC.S.,ChambersJ.E.,DickensJ.A.,MookerjeeS.,MarciniakS.J.(2018).TheintegratedstressresponseregulatesBMPsignallingthrougheffectsontranslation.BMCBIOLOGy16:34.PMID:29609607References

Gauthier,S.,VanHaaften,E.,Cherbas,L.,Cherbas,P.andHewes,R.(2012).Cryptocephal,theDrosophilamelanogasterATF4,IsaSpecificCoactivatorforEcdysoneReceptorIsoformB2.PLoSGenet,8(8),e1002883.PMID:22912598

HewesRS1,SchaeferAM,TaghertPH.(2000).Thecryptocephalgene(ATF4)encodesmultiplebasic-leucinezipperproteinscontrollingmoltingandmetamorphosisinDrosophila.Genetics.155(4),1711-1723.PMID:10924469

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。