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蚂蚁淘在线 / 品牌中心 / DiscoverX / DiscoverX/PathHunter® Panitumumab Bioassay Kit/200dp(2x96-well)/93-1051Y3-00093
商品描述
The PathHunter® Dimerization Bioassay detects ligand induced dimerization of two subunits of a receptor-dimer pair.The cells have been engineered to co-express one receptor subunit fused to Enzyme Donor (ED), and a second dimer partner fused to Enzyme Acceptor (EA).Cytoplasmic tail may have been deleted from one or both receptors.Binding of an agonist to one receptor subunit induces it to interact with its dimer partner,forcing complementation of the two enzyme fragments.This results in the formation of a functional enzyme that hydrolyzes a substrate to generate a chemiluminescent signal.
- Target/Description
- Epidermal growth factor receptor
- Group
- Receptor Tyrosine Kinase
- Cell Background
- U2OS
- Species
- Human
- Accession Number
- NM_005228.3
- Agonist/Ligand
- Recombinant Human EGF
- Antagonist/Inhibitor
- Vectibix (Panitumumab)
- Assay Measures
- EGFR/ErbB2 Dimerization
- Bioassay Target Name
- EGFR/ErbB2
- Assay Qualified With
- Vectibix®
- Drug Trademark Owner
- Vectibix® is a registered trademark of Amgen Inc.
How it works
