*Please inquire the availability for this product. Terrein is a polar, substituted dihydrocyclopentenone first reported by Raistrick and colleagues in the 1930s and subsequently found in a number of Aspergillus and Penicillium species. For many years the biological profile and mode of action of terrein was unstudied; however, recent research showed that terrein reduces melanin synthesis by reducing tyrosinase production via ERK activation, followed by MITF down-regulation. Terrein also reduces human keratinocyte proliferation by inhibiting ERK and by decreasing the expression of cyclin B1 and Cdc2 complex.

Additional Information

Synonyms	(+) Terrein, NSC 291308
Product #	T-2611
CAS #	582-46-7
Formula	C8H10O3
MW	154.2
Appearance	Light tan solid
Purity	>95% by HPLC
Boiling Point	327.2±42.0 °C at 760 mmHg
Storage Temp	-20°C
Therapeutic Area	Infectious Diseases
Use	Terrein is a bioactive fungal metabolite that has plant growth inhibition and antibacterial activities

Additional Information

MDL Number	MFCD09752761
InChI	InChI=1S/C8H10O3/c1-2-3-5-4-6(9)8(11)7(5)10/h4-4,7-8,10-11H,1H3/b3-2+/t7-,8+/m0/s1
SMILES	O=C1C=C(C=CC)[C@H](O)[C@@H]1O

盐酸贝斯他汀的应用：•急性早幼粒细胞白血病的治疗•增强了低剂量NA3的抗伤害作用•增强骨髓巨噬细胞祖细胞的增殖•增强CFU-GM菌落的形成•肺癌治疗的疗效