Teicoplanin A2-1 is a glycopeptide antibiotic obtained from actinomycetes Actinoplanes teichomyceticus isolated from soil in India. Teicoplanin A2-1 is a mixture of related glycopeptide analogues, with a basic structure characterized with a linear heptapeptide, the distinct carbohydrates D-mannose and D-glycosamine and acyl residue that carries various fatty acids which define the members of the teicoplanin complex. It shows appreciable activity against staphylococci and streptococci, corynebacteria, listeria, and clostridia. It inhibits cell wall biosynthesis in gram-positive organisms by interfering with peptidoglycan polymerization. Teicoplanin A2-1 also fights methicillinresistant Staphylococcus aureus (MRSA).
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Additional Information
| Synonyms | Targocid, Ticosin, Antibiotic L 17054 |
|---|---|
| Product # | T-2577 |
| CAS # | 91032-34-7 |
| Formula | C88H95Cl2N9O33 |
| MW | 1877.7 |
| Appearance | White solid |
| Purity | >98% by HPLC |
| Solubility | Soluble in DMSO, DMF, ethanol, methanol, and water (poorly) |
| Storage Temp | -20°C |
| Therapeutic Area | Infectious Diseases |
| Use | A glycopeptide antibiotic produced by Actinoplanes teichomyceticus |
Additional Information
| InChI | InChI=1S/C88H95Cl2N9O33/c1-3-4-5-6-7-8-9-10-60(108)94-68-74(113)71(110)58(32-101)129-87(68)132-78-55-26-40-27-56(78)126-52-18-14-38(24-47(52)90)77(131-86-67(92-34(2)103)73(112)70(109)57(31-100)128-86)69-84(121)98-66(85(122)123)45-29-42(105)30-54(127-88-76(115)75(114)72(111)59(33-102)130-88)61(45)44-23-37(13-15-49(44)106)63(81(118)99-69)96-83(120)65(40)97-82(119)64-39-21-41(104)28-43(22-39)124-53-25-36(12-16-50(53)107)62(91)80(117)93-48(79(116)95-64)20-35-11-17-51(125-55)46(89)19-35/h7-8,11-19,21-30,48,57-59,62-77,86-88,100-102,104-107,109-115H,3-6,9-10,20,31-33,91H2,1-2H3,(H,92,103)(H,93,117)(H,94,108)(H,95,116)(H,96,120)(H,97,119)(H,98,121)(H,99,118)(H,122,123)/b8-7-/t48-,57-,58-,59-,62+,63-,64+,65-,66-,67-,68-,69+,70-,71-,72-,73-,74-,75+,76+,77-,86+,87+,88+/m1/s1 |
|---|---|
| SMILES | CCCCC/C=CCCC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1Oc2c3cc4cc2Oc5ccc(cc5Cl)[C@H]([C@H]6C(=O)N[C@H](c7cc(cc(c7-c8cc(ccc8O)[C@H](C(=O)N6)NC(=O)[C@@H]4NC(=O)[C@@H]9c1cc(cc(c1)Oc1cc(ccc1O)[C@@H](C(=O)N[C@H](Cc1ccc(c(c1)Cl)O3)C(=O)N9)N)O)O[C@@H]1[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O)O)O)C(=O)O)O[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)NC(=O)C)CO)O)O |
