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商品描述
*Please inquire the availability for this product. Platensimycin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Its discovery was heralded by high profile publication and commentary in the scientific and lay press. Platensimycin was discovered by a target-based, whole-cell screening strategy using an antisense differential sensitivity assay, based on the inhibition of fatty acid synthesis. Platensimycin inhibits bacterial growth by selectively inhibiting the elongation enzyme, b-ketoacyl acyl carrier protein synthase (FabF) of the fatty acid synthesis pathway.
盐酸贝斯他汀的应用：•急性早幼粒细胞白血病的治疗•增强了低剂量NA3的抗伤害作用•增强骨髓巨噬细胞祖细胞的增殖•增强CFU-GM菌落的形成•肺癌治疗的疗效
Additional Information
| Product # | P-2781 |
|---|---|
| CAS # | 835876-32-9 |
| Formula | C24H27NO6 |
| MW | 441.2 |
| Appearance | Light tan solid |
| Purity | >95% by HPLC |
| Solubility | Soluble in DMSO (20 mg/ml), ethanol (20 mg/ml), methanol, DMF, and water (poorly) |
| Melting Point | 289.65 °C |
| Boiling Point | 683.09 °C at 760 mmHg |
| Storage Temp | -20°C |
| Therapeutic Area | Infectious Diseases |
| Use | Platensimycin is a novel, broad spectrum, Gram-positive antibiotic |
Additional Information
| MDL Number | MFCD14635440 |
|---|---|
| InChI | InChI=1S/C24H27NO7/c1-22(7-6-17(28)25-18-14(26)4-3-13(19(18)29)21(30)31)16(27)5-8-24-10-12-9-15(20(22)24)32-23(12,2)11-24/h3-5,8,12,15,20,26,29H,6-7,9-11H2,1-2H3,(H,25,28)(H,30,31)/t12-,15+,20+,22-,23-,24+/m1/s1 |
| SMILES | C[C@@]12C[C@]34C[C@H]1C[C@@H]([C@H]3[C@](C(=O)C=C4)(C)CCC(=O)Nc5c(ccc(c5O)C(=O)O)O)O2 |
