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商品描述
*PleaseinquiretheavailABIlityforthisproduct.Doxycyclineisasemi-synthetictetracyclinepreparedbyhydrogenolysisofoxytetracyclinetoremovethe6-hydroxygroup.Althoughthesynthesiswasreportedin1958,itwasnotreleasedforuseuntil1967.Doxycycline,togetherwithminocycline,isregardedasa‘thirdgeneration’tetracyclinelargelyreplacingtheanaloguesandpro-drugsproducedintheearly1960sformainstreamantibioticapplications.Likealltetracyclines,doxycyclineshowsbroadspectrumantibacterialandantiprotozoanactivityandactsbybindingtothe30Sand50Sribosomalsubunits,blockingproteinsynthesis.Doxycyclinehasbeenextensivelycitedintheliteraturewithover10,000references.
AdditionalInformation
| Synonyms | 6-Deoxy-5-hydroxytetracycline,6-Deoxyoxytetracycline,Doxytetracycline,GS3065,Hydramycin,Medeomycin,Vibramycin |
|---|---|
| Product# | D-2543 |
| CAS# | 564-25-0 |
| Formula | C22H24N2O8 |
| MW | 444.4 |
| Appearance | Yellowtoorangesolid |
| Purity | >98%byHPLC |
| MeltingPoint | 201°C |
| BoilingPoint | 762.6±60.0°Cat760mmHg |
| StorageTemp | -20°C |
| TherapeuticArea | InfectiousDiseases |
| Use | DoxycyclineisusedtotreatLymedisease,chronicprostatitis,sinusitis,pelvicinflammatorydisease,rickettsialinfections |
| MDLNumber | MFCD00800994 |
|---|---|
| InChI | InChI=1S/C22H24N2O8/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31)/t7-,10+,14+,15-,17-,22-/m0/s1 |
| SMILES | C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=C(C(=O)[C@]3(C(=C2C(=O)C4=C1C=CC=C4O)O)O)C(=O)N)O)N(C)C)O |
