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商品描述
Curvularinisa12-memberedmacrocycliclactoneincorporatingaresorcinylmoiety,producedbyanumberoffungalspeciesincludingCurvularia,PenicilliumandAlternaria.CurvularinexhibitsadistinctlydifferentBIOLOGicalprofiletothestructurallysimilarresorcylicacidlactonessuchasthezearalenones,rADIcicolandLLZ1640-2.Curvularininhibitscelldivisionbydisruptingmitoticspindleformationandisknowntobephytotoxic.Morerecentinvestigationshaveshownthatcurvularinisahighlyselectivetranscription-basedinhibitorofiNOS-dependentNOproduction,actingontheJanustyrosinekinase-STATpathway.ThisactionoffersanapproachtothedevelopmentofdrugsinhibitingiNOSoverproductionassociatedwithNOpathophysiology.
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AdditionalInformation
| Synonyms | S-Curvularin,NSC166071 |
|---|---|
| Product# | C-2675 |
| CAS# | 10140-70-2 |
| Formula | C16H20O5 |
| MW | 292.3 |
| Appearance | Whitesolid |
| Purity | >99%byHPLC |
| Solubility | Solubleinmethanol,dioxane,pyridine |
| BoilingPoint | 557.0±29.0°Cat760mmHg |
| StorageTemp | -20°C |
| Use | ApotentantifungalandmycotoxinthatalsoinhibitsNOproduction |
| MDLNumber | MFCD09752718 |
|---|---|
| InChI | InChI=1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3/t10-/m0/s1 |
| SMILES | C[C@H]1CCCCCC(=O)c2c(cc(cc2O)O)CC(=O)O1 |
