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蚂蚁淘在线 / 品牌中心 / AG Scientific / AG Scientific/DTE (1,4-Dithioerythritol)/1 g/D-2589-1 g

AG Scientific/DTE (1,4-Dithioerythritol)/1 g/D-2589-1 g

价格
￥815.80
货号：D-2589-1g
浏览量：126
品牌：AG Scientific
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商品描述
Cat#:ACC-116
AlternativeNameInositol1,4,5-trisphosphatereceptortype2,IP3R2,InsP3R2,IP3receptorisoform2
  • LyophilizedPowder
  • AntigenIncl.
    • Type:Polyclonal
    Host:Rabbit
    Reactivity:r
    Mayalsoworkin:h*,m*
      • Peptide(C)RLGFLGSNTPHENH,correspondingtoaminoacidresidues2683-2696ofratIP3R2(Accession P29995). Intracellular,C-terminus.
        Anti-IP3 Receptor-2 (ITPR2) Antibody
    Accession(Uniprot)NumberP29995
    GeneID81678
    PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.
    HomologyMouse,human-13/14aminoacidresiduesidentical.
    RRIDAB_2340910.
    PurityAffinitypurifiedonimmobilizedantigen.
    FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN3.
    IsotypeRabbitIgG.
    StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.
    Reconstitution25µl,50µlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.
    Antibodyconcentrationafterreconstitution0.8mg/ml.
    StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).
    NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.
    Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).
    Negativecontrolantigenstorageafterreconstitution-20°C.
    PreadsorptionControl1µgpeptideper1µgantibody.
    StandardqualitycontrolofeachlotWesternblotanalysis.
    Applications:if,ih,wb
    Mayalsoworkin:ic*,ifc*,ip*
      • Anti-IP3 Receptor-2 (ITPR2) Antibody
        Westernblotanalysisofratbrainmembrane(lanes1and3)andratbasophilicleukemia(RBL)celllinelysate(lanes2and4):
        1,2. Anti-IP3 Receptor-2 (ITPR2) Antibody(#ACC-116),(1:200).
        3,4.Anti-IP3 Receptor-2(ITPR2)Antibody,preincubatedwiththenegativecontrolantigen.
      • Anti-IP3 Receptor-2 (ITPR2) Antibody
        ExpressionofIP3R2inratspinalcord
        ImmunohistochemicalstainingofIP3R2inratspinalcordsectionsusing Anti-IP3 Receptor-2(ITPR2)Antibody(#ACC-116). A.IP3R2immunoreactivity(red)appearsinneuronalsoma(horizontalarrows)andprocesses(verticalarrows).B.NuclearstainingusingDAPIasthecounterstain(blue).C.MergedimageofAandB.
    References
    • 1.Furuichi,T.etal.(1989)Nature342,32.
    • 2.Berridge,M.J.etal.(2003)Nat.Rev.Mol.CellBiol.4,517.
    • 3.Furuichi,T.etal.(1994)Curr.Opin.Neurobiol.4,294.
    • 4.Varnai,P.etal.(2005)Proc.Natl.Acad.Sci.U.S.A.102,7859.
    • 5.Fujino,I.etal.(1995)CellTissueRes.280,201.
    • 6.Yaroslavskiy,B.B.etal.(2007)J.CellSci.120,2884.

      • Inositol1,4,5-trisphosphatereceptors(IP3R)areintracellularCa2+ releasechannelslocatedontheendoplasmicreticulum(ER)andmediateCa2+ mobilizationfromtheERtothecytoplasminresponsetothebindingofthesecondmessenger,inositol1,4,5-trisphosphate(IP3)1.IP3-inducedCa2+ releaseistriggeredbyvariousexternalstimuli,andmostnon-excitablecellsusethismechanismastheprimaryCa2+ signalingpathway.IP3Rsarethereforethoughttohaveimportantphysiologicalrolesinvariouscelltypesandtissues2.

        ThreesubtypesofIP3Rs,derivedfromthreedistinctgenes,havebeenidentifiedinmammals3.AllthreereceptorshavesixtransmembranedomainsandaporeregionbetweenTM5andTM6.TheN-terminusaswellastheC-terminusarecytoplasmic.EachIP3RconsistsofanN-terminalligandbindingdomain(LBD)andaC-terminaldomainwhichislinkedbyalongregulatorydomain.TheC-terminusisconstitutivelyactive,suggestingthattheregulatorydomainisrequiredtomaintainthesuppressionofchannelactivity4. 

        Type2IP3R(IP3R2)isexpressedinvarioustissuesandcelllines.IP3R2mRNAislocalizedintheintralobularductcellsofthesuBMAndibulargland,theurinarytubulecellsofthekidney,theepithelialcellsofepididymalductsandthefolliculargranulosacellsoftheovary5.IP3R2isactiveduringosteoclastdifferentiation,anditsabsencecausesapartialdefectinosteoclasticdifferentiation.

    Applicationkey:

    CBE-Cell-basedELISA,FC-Flowcytometry,ICC-Immunocytochemistry,IE-IndirectELISA,IFC-Indirectflowcytometry,
    IF-Immunofluorescence,IHC-Immunohistochemistry,IP-Immunoprecipitation,LCI-Livecellimaging,N-Neutralization,WB-Westernblot

    Speciesreactivitykey:

    H-Human,M-Mouse,R-Rat
    LyophilizedPowderNegativeControlAntigenIncluded
    receivea25µlfreetrialsample!
    Lastupdate:10/11/2019

    Anti-IP3Receptor-2(ITPR2)Antibody(#ACC-116)isahighlyspecificantibodydirectedagainstanepitopeoftheratprotein.Theantibody canbeusedinwesternblotandimmunohistochemistryapplications.IthasbeendesignedtorecognizeIP3R2fromrat,mouseandhumansamples.

    Forresearchpurposesonly,notforhumanuse
    盐酸贝斯他汀的应用：•急性早幼粒细胞白血病的治疗•增强了低剂量NA3的抗伤害作用•增强骨髓巨噬细胞祖细胞的增殖•增强CFU-GM菌落的形成•肺癌治疗的疗效

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