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商品描述
More Information
Alternate Name/Synonyms
Ubenimex hydrochloride
SKU
B-1075
CAS #
65391-42-6
Chemical Name
(2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid;hydrochloride
Chemical Formula
C16H24N2O4 • HCl
Molecular Weight
344.8 Da
Appearance
White powder
Purity
≥98% (HPLC)
Solubility
Clear to slightly hazy 10mg/ml in water, Up to 20mg/ml in HCI and Up to 5mg/ml in MeOH.
Melting Point
213-215°C
Preparation
N/A
Storage Temp
-20°C, desiccated
THERAPEUTIC AREA
Oncological disorders
USE
Bestatin hydrochloride is a reversible inhibitor of aminopeptidase enzymes, namely Aminopeptidase B, Aminopeptidase M (CD13), and leucine aminopeptidase (LAP3). Inhibition of these proteins by bestatin correlates to apoptosis induction in oncogenic cells. Bestatin is also a potent inhibitor of leukotriene A4 hydrolase (LTA4), potentially allowing investigation of the role of LTA4 in inflammation.
Merck Index
N/A
MDL NUMBER
MFCD00058004
CHEMACX
X1087674-3
INCHI
InChI=1S/C16H24N2O4.ClH/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11;/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22);1H/t12-,13+,14+;/m1./s1
SMILES
CC(C)C[C@@H](C(=O)O)NC(=O)[C@H]([C@@H](Cc1ccccc1)N)O.Cl
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product. Use with local exhaust ventilation. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
Downloads Title
MSDS Documentation
msds 1
B-1075, Bestatin HCl, SDS, diamond format.pdf
Certificate of Analysis 1
B-1075, J1212B.pdf
Certificate of Analysis 2
B-1075, J1212A.pdf
Certificate of Analysis 3
B-1075, J1212.pdf
