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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
MoreInformation
AlternateName/Synonyms
ZK-62711
SKU
R-1012
CAS#
61413-54-5
ChemicalName
4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
ChemicalFormula
C16H21NO3
MolecularWeight
275.4Da
Appearance
Whitesolid
Purity
≥98%
Solubility
SolubleinWater
MeltingPoint
132°C
Preparation
N/A
StorageTemp
4°C,desiccated
THERAPEUTICAREA
NeurodegenrativeDiseases
USE
Rolipramisaselective,cell-permeableinhibitorofcAMP-specificPDE(phosphodiesterase)(PDE4,IC50=1μM).ThiscompoundhasbeenshowntoinhibitPDE4activityinhumancavernosaltissue,whichinterruptsthesignaltransductionpathwayoferectileresponse.RoliprampromotesapoptosisinHL60cellsthroughacAMP-independentmechanismandhasbeenshowntoenhanceneuronalsurvival.RolipramisaninhibitorofPDE4A1andPDE4B.
MerckIndex
13.8332.2001
MDLNUMBER
MFCD00270906
CHEMACX
X1038250-2
INCHI
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
SMILES
COc1ccc(cc1OC2CCCC2)C3CC(=O)NC3
RTECS
UY5749237
Handling
FurtherprocessingofsolidmaterialsmayresultintheformationofcombustIBLedusts.Thepotentialforcombustibledustformationshouldbetakenintoconsiderationbeforeadditionalprocessingoccurs.Provideappropriateexhaustventilationatplaceswheredustisformed.
Citations
BEHAVIORAL/SYSTEMS/COGNITIVE:Phosphodiesterase-4DKnock-OutandRNAInterference-MediatedKnock-DownEnhanceMemoryandIncreaseHippocampalNeurogenesisviaIncreasedcAMPSignalingYun-FengLi,Yu-FangCheng,YingHuang,MarcoConti,StevenP.Wilson,JamesM.O"Donnell,andHan-TingZhangJ.Neurosci.,Jan2011;31:172-183.
Citations_Hyperlink
http://www.jneurosci.org/cgi/reprint/31/1/172
MSDs1
R-1012,Rolipram,SDS,diamondformat.pdf
CertificateofAnalysis1
R-1012,F1254E.pdf
CertificateofAnalysis2
R-1012,F1254D.pdf
CertificateofAnalysis3
R-1012,F1254C.pdf
