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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
AnovelspecificinhibitoroftheJumonjifamilyofhistonedemethylasesinvitro,incancercellsandintumorsinvivo.IC50=230,340,435,445,855and1100nMforJARID1A,JMJD2E,JMJD2B,JMJD2A,JMJD3andJMJD2Crespectively. Reducestumorburdenandprolongslifeinamousemodel.SuppressestranslationinitiationandenhancesmTORinhibitorsensitivity.Inhibitsthegrowthoftemozolomide-resistantglioblastomacellsandcrossesthebloodbrainbarrier.
ArecentstudyhasshownthatJIB-04increasestheexpressionofPD-L1in SUM149-MAbreastcancercelllines.IncreasedPD-L1expressioninbreastcancercelllinesrendersthemresponsivetovarioustherapiesnotjustimmunecheckpointblockadeofPD-L1.HencetheseresultssuggestthatJIB-04isapotentialanti-canceragentthatcanhaltcancerprogressionandpreventresistancetotherapies.
AdditionalInformation
| Product# | J-2519 |
|---|---|
| CAS# | 199596-05-9 |
| ChemicalName | (E)-5-chloro-2-(2-(phenyl(pyridin-2-yl)methylene)hydrazinyl)pyridine |
| Formula | C170H13CIN4 |
| MW | 308.8 |
| Appearance | yellowpowder |
| Purity | >98%(TLC);NMR(Conforms) |
| Solubility | MaybedissolvedinDMSO(30mg/ml) |
| StorageTemp | Storedesiccatedassuppliedat-20°Cforupto2years.Storesolutionsat-20°Cforupto2months. |
