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商品描述
More Information
Alternate Name/Synonyms
Calcium Ionophore A23187; Calcimycin; Antibiotic A23187; Calcium Ionophore
SKU
A-1020
CAS #
52665-69-7
Chemical Name
5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid
Chemical Formula
C29H37N3O6
Molecular Weight
523.60 Da
Appearance
White powder
Purity
≥98%
Solubility
DMSO, methanol, dicholormethane. Slightly soluble in water.
Melting Point
190°C
Preparation
N/A
Storage Temp
-20°C
THERAPEUTIC AREA
Infectious Diseases
USE
A23187 has antibiotic properties against gram positive bacteria and fungi. Calcium ionophore.
Merck Index
N/A
MDL NUMBER
MFCD00151202
CHEMACX
X1001942-8
INCHI
InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1
SMILES
C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)c3ccc[nH]3)C)C)O[C@H]1Cc4nc5c(o4)ccc(c5C(=O)O)NC
Peptide sequence
Not Applicable
RTECS
NO0600000
UN #"S
N/A
PACKING GROUP
N/A
HAZARD CLASS
N/A
Handling
Avoid contact with skin, eyes or clothing. Use personal protective equipment as required. Wash contaminated clothing before reuse. Do not breathe dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using this product
Citations
MECHANISMS OF SIGNAL TRANSDUCTION:Identification of Nitric Oxide as an Endogenous Activator of the AMP-activated Protein Kinase in Vascular Endothelial CellsJunhua Zhang, Zhonglin Xie, Yunzhou Dong, Shuangxi Wang, Chao Liu, and Ming-Hui ZouJ. Biol. Chem., Oct 2008; 283: 27452 - 27461.
Citations_Hyperlink
http://www.jbc.org/cgi/reprint/283/41/27452
msds 1
A-1020, A2318, SDS, diamond format.pdf
Certificate of Analysis 1
A-1020, G1328B.pdf
Certificate of Analysis 2
A-1020, G1328.pdf
Certificate of Analysis 3
A-1020, G1239.pdf
