Clophosome®- ClodronateLiposomes(Neutral)

Clophosome®,neutralclodronateliposomes,offershighlyefficientinvivomacrophage depletion.ClodronatemoleculesareencapsulatedinsmallMLVliposomesforsuperioractivity,physicalandchemicalstability,andconvenienceofuse.Itisformulatedtoanexceptionallyhighclodronate/lipidratio.Freeclodronateiscleanedoutandtheliposomalclodronate encapsulationefficiencyismorethan90%.Clophosomeliposomesremainhomogenousandsuspendedevenafterlongtermstorageinfridge.Itisnotviscousandeasytoinject. Itismanufacturedsterile forlongtermshelf-life. 

Theproductissuitablefordosingwithvariousroutesincluding intravenous,intraperitoneal,subcutaneous,intranasal, intratrachealandetc. Wehaveachieved80-90%macrophagedepletioninspleen(redpulpmacrophages)24hoursafterasingle0.2mLintravenousinjection. Astartingdoseof0.15-0.2mL(i.v.ori.p.)for20-25g animalbodyweightisrecommendedforgoodconsistencyinmacrophagedepletion.Optimizationisrecommendedforyourspecificapplications.

Specifications

Productcode:F70101C-N 

BrandName:Clophosome®

Active: clodronatedisodium. CAS:22560-50-5,7mg/mL

Lipidcomposition: phosphatidylcholineandcholesterol

Bulksolution: phosphatebufferedsucrose(20mM sodium phosphate,10%sucrose),pH7.0-7.5

Shelf-life: 6months guaranteedforunopenedvials

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