抗辣根过氧化物酶

Fitzgerald/PAPPA antibody/107951/1 mg

OVERVIEW:

SynonymsMonoclonalPAPPAantibody,Anti-PAPPAantibody,PAPPAantibody,PAPPAantibody,PAPPAantibody,PregnancyAssociatedPlasmaProteinAantibody,AntiPAPPAantibody,PAPP-Aantibody,PAPP-Aantibody,PregnancyAssociatedPlasmaProteinAantibody
SpecificityHumanPAPPA
ApplicationsELISA,Immunoassays,IP
ImmunogenPAPPAantibodywasraisedinmouseusingpurifiedhumanPAPP-A/proMBPcomplexastheimmunogen.
AssayInformation10-7951canbeusedinasandwichimmunoassayasacoatingantibodyinconjunctionwith10-7952astheconjugateantibody

SPECIFICATIONS:

HostMouse
CloneM18612PP1
IsotypeIgG2a
MethodofPurificationPAPPAantibodywaspurifiedbyProteinAchromatography.
Form&BufferSuppliedinPBS,pH7.4,0.1%sodiumazide(NaN3)

STORAGE&SAFETY:

StorageStoreat4DegC
BiohazardInformationThisproductissoldasanantibodypreparationforresearchuseonly.StandardLaboratoryPracticesshouldbefollowedwhenhandlingthismaterial.Containssodiumazide(0.1%)aspreservative.Althoughtheamountofsodiumazideisverysmallappropria

GENERALINFORMATION:

BIOLOGicalSignificancePregnancy-associatedplasmaproteinA,pappalysin1,alsoknownasPAPPA,isaproteinusedinscreeningtestsforDownsyndrome.PAPPAisasecretedmetalloproteinasewhichcleavesinsulin-likegrowthfactorbindingproteins(IGFBPs).Itisthoughttobeinvolvedinlocalproliferativeprocessessuchaswoundhealingandboneremodeling.LowplasmalevelofthisproteinhasbeensuggestedasabiochemicalMarkerforpregnancieswithaneuploidfetuses

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