Adipogen/antiCathepsin D, pAb/YIFLFPA0204/100 µl相关交流-蚂蚁淘在线

Adipogen/antiCathepsin D, pAb/YIFLFPA0204/100 µl

mayitao /发布时间:1631122203 /浏览量:221

MoreInformation
ProductDetails
Synonyms	CTSD;CPSD;EC=3.4.23.5
ProductType	PolyclonalAntibody
Properties
Immunogen/Antigen	RecombinanthumanHis-CathepsinDproteinpurifiedfromE.coli.
Application	WesternBlot(1:5,000)
Crossreactivity	Human Rat
PurityDetail	Affinitypurification.
Concentration	1mg/ml
Formulation	Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol.
OtherProductData	ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
Declaration	ManufacturedbyAbFrontier
ShippingandHandling
Shipping	BLUEICE
ShortTermStorage	+4°C
LongTermStorage	-20°C
Use/Stability	Stableforatleast1yearafterreceiptwhenstoredat-20°C.
Documents
MSDS	No
ProductSpecificationSheet
Datasheet	DownloadPDF

CathepsinD(CatD)isaubiquitouslyexpressedlysosomalaspartylproteaseinvolvedinthenormaldegradationofproteinsapoptosisandautophagy.HumanCatDissynthesizedontheendoplasmicreticulumasapre-pro-enzyme.PreprocathepsinD(412aa)iscleavedandglycosylatedtoformaninactiveprocathepsinD(392aa)andthenfurthercleavedtogenerateanactiveintermediate(348aa)single-chainmolecule.TheactiveintermediateisfurtherprocessedintomaturetwochainformofcathepsinD,thisprocessingstepiscarriedoutbycathepsinBorL.Thetwo-chainformconsistsofanaminoterminallightchain(14kDa)andacarboxyl-terminalheavychain(34kDa).Additionally,severalmoreaminoacidsareremovedfromthecarboxylterminusofthe34kDaheavychain.ProcathepsinD(pCD),secretedfromcancercells,actsasamitogenonbothcancerandstromalcellsandstimulatestheirproinvasiveandpro-metastaticproperties.Acidproteaseactiveinintracellularproteinbreakdown.InvolvedinthepathogenesisofseveraldiseasessuchasbreastcancerandpossiblyAlzheimerdisease.

ProductReferences

1)ZaidiNetal.,(2008)BiochemBiophysResCommun7;376(1):5-9.(General)
2)Liaudet-Coopman,E.etal.,(2006)CancerLett237,167-179.(General)

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