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Adipogen/antiCathepsin D, pAb/YIFLFPA0204/100 µl
mayitao
/发布时间:1631122203 /浏览量:265
| ProductDetails | |
|---|---|
| Synonyms | CTSD;CPSD;EC=3.4.23.5 |
| ProductType | PolyclonalAntibody |
| Properties | |
| Immunogen/Antigen | RecombinanthumanHis-CathepsinDproteinpurifiedfromE.coli. |
| Application | WesternBlot(1:5,000) |
| Crossreactivity | Human Rat |
| PurityDetail | Affinitypurification. |
| Concentration | 1mg/ml |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/Stability | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CathepsinD(CatD)isaubiquitouslyexpressedlysosomalaspartylproteaseinvolvedinthenormaldegradationofproteinsapoptosisandautophagy.HumanCatDissynthesizedontheendoplasmicreticulumasapre-pro-enzyme.PreprocathepsinD(412aa)iscleavedandglycosylatedtoformaninactiveprocathepsinD(392aa)andthenfurthercleavedtogenerateanactiveintermediate(348aa)single-chainmolecule.TheactiveintermediateisfurtherprocessedintomaturetwochainformofcathepsinD,thisprocessingstepiscarriedoutbycathepsinBorL.Thetwo-chainformconsistsofanaminoterminallightchain(14kDa)andacarboxyl-terminalheavychain(34kDa).Additionally,severalmoreaminoacidsareremovedfromthecarboxylterminusofthe34kDaheavychain.ProcathepsinD(pCD),secretedfromcancercells,actsasamitogenonbothcancerandstromalcellsandstimulatestheirproinvasiveandpro-metastaticproperties.Acidproteaseactiveinintracellularproteinbreakdown.InvolvedinthepathogenesisofseveraldiseasessuchasbreastcancerandpossiblyAlzheimerdisease.
ProductReferences
1)ZaidiNetal.,(2008)BiochemBiophysResCommun7;376(1):5-9.(General)
2)Liaudet-Coopman,E.etal.,(2006)CancerLett237,167-179.(General)
2)Liaudet-Coopman,E.etal.,(2006)CancerLett237,167-179.(General)
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