Adipogen/Actinomycin D/BVT0089M005/5 mg

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ProductDetails
Synonyms	ActinomycinIV;ActinomycinC1;Dactinomycin
ProductType	Chemical
Properties
Formula	C62H86N12O16
MW	1255.4
MerckIndex	14:2800
CAS	50-76-0
RTECS	AU1575000
Source/HostChemicals	IsolatedfromStreptomycesparvulus.
PurityChemicals	≥98%(HPLC)
Appearance	Redshinycrystals.
Solubility	SolubleinDMSO,100%ethanolormethanol.
Identity	Determinedby1H-NMR.
Declaration	ManufacturedbyBioViotica.
OtherProductData	Sensitivetostrongacidsandbases.
InChiKey	ZOWMRHVAQGTFTG-IZRKADTCSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	+4°C
HandlingAdvice	Keepcoolanddry. Protectfromlightwheninsolution.
Use/Stability	Stableforatleast1yearafterreceiptwhenstoredat+4°C. Afterreconstitutionprotectfromlightat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

• Antibiotic.
• Antitumorcompound[2].
• Cytotoxic[2].
• Apoptosisinducer[1,2,6,7].
• RNAsynthesisinhibitor[4].
• DNAintercalatingagent[3,5].
• Mcl-1expressioninhibitor[8]
• p53pathwayactivator[9].

ProductReferences

1. ApoptosisinducedbyActinomycinD,CamptothecinorAphidicolincanoccurinallphasesofthecellcycle:J.M.Glynn,etal.;Biochem.Soc.Trans.20,84S(1992)
2. ActinomycinDinducesapoptosisandinhibitsgrowthofpancreaticcancercells:J.Kleeff,etal.;Int.J.Cancer86,399(2000)
3. InfluenceofDNAbasesequenceonthebindingenergeticsofactinomycinD:S.A.Bailey,etal.;Biochemistry32,5881(1993)
4. EffectofactinomycinonRNAsynthesisandantibodyformationintheanamnesticresponseinvitro:J.D.Smiley,etal.;J.Exp.Med.119,881(1964)
5. NMRSolutionStructureofaDNA-ActinomycinDComplexContainingaNon-Hydrogen-BondingPairintheBindingSite:S.L.Cravens,etal.;J.Am.Chem.Soc. 132,17588 (2010)
6. ActinomycinDupregulatesproapoptoticproteinPumaanddownregulatesBcl-2mRNAinnormalperipheralbloodlymphocytes:I.Kalousek,etal.;AnticancerDrugs18,763(2007)
7. ActinomycinDenhancesTRAIL-inducedcaspase-dependentand-independentapoptosisinSH-SY5Yneuroblastomacells:M.J.Wang,etal.;Neurosci.Res.59,40(2007)
8. ActinomycinDsynergisticallyenhancestheefficacyoftheBH3mimeticABT-737bydownregulatingMcl-1expression:K.E.Olberding,etal.;CancerBiol.Ther.10,930(2010)
9. Specificactivationofthep53pathwaybylowdoseactinomycinD:M.L.Choong,etal.;CellCycle8,2810(2009)

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