河豚毒素单克隆抗体相关交流-蚂蚁淘在线

河豚毒素单克隆抗体

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MouseAnti-TTX(5E7) antibody

产品编号	hzm-0919M
英文名称	TTX(5E7)
中文名称	河豚毒素单克隆抗体
别名	TETRODOTOXIN;Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol

产品类型	药物与化合物抗体
研究领域	免疫学药物及化合物海洋生物
抗体来源	Mouse
克隆类型	Monoclonal
克隆号	5E7
交叉反应	TTX
产品应用	ELISA=1:500-1000 （石蜡切片需做抗原修复） notyettestedinotherapplications.optimaldilutions/concentrationsshouldbedeterminedbytheenduser.
分子量	0.31927kDa
性状	LyophilizedorLiquid
浓度	1mg/ml
免疫原	KLHconjugatedtoTTX:
亚型	IgG
纯化方法	affinitypurifiedbyProteinG
储存液	0.01MTBS(pH7.4)with1%BSA,0.03%Proclin300and50%Glycerol.
保存条件	Storeat-20°Cforoneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20°C.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibodytheantibodyisstableforatleasttwoweeksat2-4°C.
PubMed	PubMed
产品介绍	background:Tetrodotoxin,frequentlyabbreviatedasTTX,isapotentneurotoxinwithnoknownantidote.Therehavebeensuccessfultestsofapossibleantidoteinmice,butfurthertestsmustbecarriedouttodetermineefficacyinhumans.Fampridinehasbeenshowntoreversetetrodotoxintoxicityinanimalexperiments.Tetrodotoxinblocksactionpotentialsinnervesbybindingtothevoltage-gated,fastsodiumchannelsinnervecellmembranes,essentiallypreventinganyaffectednervecellsfromfiringbyblockingthechannelsusedintheprocess.Thebindingsiteofthistoxinislocatedattheporeopeningofthevoltage-gatedNa+channel.ItsnamederivesfromTetraodontiformes,anorderthatincludespufferfish,porcupinefish,oceansunfishormola,andtriggerfish,severalspeciesthatcarrythetoxin.Althoughtetrodotoxinwasdiscoveredinthesefishandfoundinseveralotheranimals(e.g.,blue-ringedoctopus,rough-skinnednewt,andNaticidae)itisactuallyproducedbycertainsymbioticbacteria,suchasPseudoalteromonastetraodonis,certainspeciesofPseudomonasandVibrio,aswellassomeothersthatresidewithintheseanimals.SWISS:N/ACAS:4368-28-9ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications

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