细胞凋亡

Role of MEF2D in Tcell Apoptosis

Mef2(Myocyteenhancerfactor2)transcriptionfactorsplayaroleinT-CellCalciumInducedApoptosis.SeveralfactorsregulateMef2transcriptionfactors,includingMapkinasesandhistonedeacetylase(HDAC)enzymes.SeealsoControlofskeletalmyogenesisbyHDAC&calcium/calmodulin-dependentkinase(CaMK)pathway.

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REFERENCES:EsauC,BoesM,YounHD,TattersonL,LiuJO,ChenJ.Deletionofcalcineurinandmyocyteenhancerfactor2(MEF2)bindingdomainofCABIn1resultsinenhancedcytokinegeneexpressioninTcells.JExpMed.2001Nov19;194(10):1449-59.KimMJ,JoDG,HongGS,KimBJ,LaiM,ChoDH,KimKW,BandyopadhyayA,HongYM,KimdoH,ChoC,LiuJO,SnyderSH,JungYK.Calpain-dependentcleavageofcain/cabin1activatescalcineurintomediatecalcium-triggeredcelldeath.ProcNatlAcadSciUSA.2002Jul23;99(15):9870-5.LiuW,YounHD,LiuJO.Thapsigargin-inducedapoptosisinvolvesCabin1-MEF2-mediatedinductionofNur77.EurJImmunol.2001Jun;31(6):1757-64.SunL,YounHD,LohC,StolowM,HeW,LiuJO.Cabin1,anegativeregulatorforcalcineurinsignalinginTlymphocytes.Immunity.1998Jun;8(6):703-11.YounHD,ChatilaTA,LiuJO.IntegrationofcalcineurinandMEF2signalsbythecoactivatorp300duringT-cellapoptosis.EMBOJ.2000Aug15;19(16):4323-31.YounHD,LiuJO.Cabin1repressesMEF2-dependentNur77expressionandTcellapoptosisbycontrollingassociationofhistonedeacetylasesandacetylaseswithMEF2.Immunity.2000Jul;13(1):85-94.YounHD,SunL,PrywesR,LiuJO.ApoptosisofTcellsmediatedbyCa2+-inducedreleaseofthetranscriptionfactorMEF2.Science.1999Oct22;286(5440):790-3.

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