Adipogen/CCT244747/SYN1216M010/10 mg

苏州蚂蚁淘  /发布时间:1631815207 /浏览量:59   

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ProductDetails
Synonyms	(R)-3-((1-(Dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile
ProductType	Chemical
Properties
Formula	C20H24N8O2
MW	408.5
CAS	1404095-34-6
PurityChemicals	≥95%
Appearance	Solid.
Solubility	SolubleinDMSO.
Declaration	ManufacturedbySynKinase.
OtherProductData	Target:CHK1|KinaseGroup:CAMK|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKey	IENLGMOXAQMNEH-CYBMUJFWSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
Use/Stability	Stableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

CCT244747isanovel,potent,highlyselective,orallyactive,ATPcompetitiveCHK1inhibitor.CCT244747caninhibitcellularCHK1activitywithanIC₅₀of29-170nM.Inmultipletumourcellmodels,thishastheeffectofsignificantlyenhancingthecytotoxicityofseveralanticancerdrugs(suchasgemcitabineandirinotecan)andabrogatingdrug-inducedSandG2arrest.

ProductReferences

1. Discoveryof3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrilesasselective,orallybioavailableCHK1inhibitors:M.Lainchbury,etal.;J.Med.Chem.55,10229(2012)
2. CCT244747isanovelpotentandselectiveCHK1inhibitorwithoralefficacyaloneandincombinationwithgenotoxicanticancerdrugs:M.I.Walton,etal.;Clin.CancerRes.18,5650(2012)

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