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Salmon thrombin （三文鱼凝血酶/鲑鱼凝血酶）

Catalog Number

SEA-135

Description

Plasma protein from the blood of farmed S. salar

Product Background

Background: 
- Fibrin gels made from salmon proteins have demonstrated remarkable properties in neuron survival and growth. 
- Salmon fibrin gels represent the optimal matrix for neuronal cell cultural
- Salmon fibrin gels have also properties superior to mammalian gels in an in vitro angiogenesis model. The salmon gels were 60-188% more efficient than human fibrin gels supporting growth of human endothetlial cells. These results indicate that salmon fibrin may be attractive alternate ECM for support of microvascular network formation. 
- Salmon fibrinogen and thrombin can be used at room temperature 
- Soft salmon fibrin gels have been shown to promote selection and growth of tumorigenic cells

Research Targets:
- Regenerative Medicine  
- Spinal Cord Injury 
- Neural cell regrowth 
- Pain & CNS Investigators 
- Stem Cell Research 
- Cancer stem cell research

Benefits: 
- Superior Performance- demonstrated superiority to Matrigel as an extracellular matrix for neuronal cell growth.
- Safety from mammalian pathogens 
- Easy of rehydration & improved thermal properties.

For more information on Salmon fibrinogen and thrombin: 
Sieminski and Gooch. 2004. J Biomater Sci Polym. Ed 15(2):237-42
Ju, et al. Biomaterials. 2007 April; 28 (12): 2097-2108 
Liu J, et al. Nat Mater. 2012 Jul 1;11(8):734-41. doi: 10.1038/nmat3361.
Information Sheet 
Application Note 

Category

Miscellaneous Proteins

Formulation

Dialyzed in 200 mM Tris, 3 mM CaCl2, 0.15M NaCl, pH 7.2-7.5.
 

Reconstitution

Rehydrate with H2O at room temperature or below. Remove the amount to be used that day, and hold on ice. Salmon thrombin retains greater than 80% activity after 24 hours on ice. Aliquot remaining thrombin and freeze at <-60°C 

Storage

Freezer (<-10°C). Avoid freeze-thaw cycles

Purity

Affinity chromatography on immobilized heparin, SDS-PAGE

Sourced from salmon shown by certified tests to be negative for fish viruses. Activity tested by spectrophometric analysis of peptide hydrolysis (Chromozyme), and compared to human standard.
Filtered to 0.2 u 

Activity

≥ 1000 Units/ mg protein

References

US Patent #6,007,811 and 6,861,225. Michaud et al, 2002. Thrombosis Research 107:245-54 

Sieminski and Gooch. 2004. J Biomater Sci Polym. Ed 15(2):237-42

Ju, et al. Biomaterials. 2007 April; 28 (12): 2097-2108 

Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation

Liu J, et al. Nat Mater. 2012 Jul 1;11(8):734-41. doi: 10.1038/nmat3361.
 

Reagent Proteins is the Source for proteins. 
From custom protein production to our over 5,000 catalog proteins, we are a leading supplier of reagent, pre-clinical and cGMP grade proteins to the biopharmaceutical and vaccine development community. We ensure the cost-effective and rapid delivery of high quality recombinant proteins to enable your research and development efforts.