Product Specification:

Alternative Name:	Bone sialoprotein 1, Secreted phosphoprotein 1, OPN, SPP1
Host:	Rabbit
Immunogen:	Synthetic peptide corresponding to aa 59-74 (P59SKSNESHDHMDDMDD74) of mature human osteopontin.
UniProt ID:	P10451
Gene/Protein Identifier:	6696 (Entrez GeneID)
Species reactivity:	Human, Mouse
Crossreactivity:	Does not cross-react with human osteonectin or bone sialoprotein.
Applications:	ELISA, IHC (PS), WB
Recommended Dilutions/Conditions:	ELISA (1:1,000) Immunohistochemistry (paraffin sections, 1:100-1:1500) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.
Formulation:	Lyophilized. From neat/unpurified rabbit serum.
Reconstitution:	Reconstitute with 20µl or 100µl distilled water.
Handling:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Shipping:	Shipped on Blue Ice
Long Term Storage:	+4°C
Scientific Background:	Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

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