Product Specification:
| Alternative Name: | BCL2L7 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to a portion of human Bak. |
| UniProt ID: | Q16611 |
| Gene/Protein Identifier: | S58873 (PIR) |
| Species reactivity: | HumanHamster, Monkey, Porcine |
| Applications: | IF, IHC, IP, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (1:50)Immunoprecipitation(1:100)Western Blot (1:1,000, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~30kDa by Western blot. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | Bax is an appromimately 22 kDa pro-apoptotic protein belonging to the Bcl-2 family of proteins, which are characterized by the presence of at least one Bcl-2 homology (BH) domains. Bax normally resides in the cytoplasm, but following an apoptotic stimuli, Bax undergoes a conformational change and translocates to mitochondrial membranes where it inserts and mediates the release of cytochrome c. This activates caspase-3 and perpetuates the apoptotic cascade. |
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