Product Specification:
| Alternative Name: | B-lymphocyte antigen CD20 |
| Clone: | RMC20-1 |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | Full length human CD20. |
| UniProt ID: | P11836 |
| Species reactivity: | Human |
| Applications: | IHC (PS) |
| Recommended Dilutions/Conditions: | Immunohistochemistry (formalin-fixed paraffin sections) (0.5-1 µg/mL) for 30 minutes at RTSuggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells. It has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that it acts as a calcium channel in the cell membrane. It has been shown that CD20 plays a role in the microenvironmental interactions of B cells. [Wiki] |
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