Product Specification:
| Alternative Name: | Brutons tyrosine kinase |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of human BTK. |
| UniProt ID: | Q06187 |
| Species reactivity: | Human, Mouse |
| Applications: | ICC, WB |
| Recommended Dilutions/Conditions: | Immunocytochemistry (10µg/ml)Western Blot (0.5-1.0µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~77kDa by Western blot. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | +4°C |
| Scientific Background: | Brutons tyrosine kinase (BTK) was initially identified as a member of the Src family of protein-tyrosine kinases that was involved in X-linked agammaglobulinaemia, and has since been shown to be involved in a number of signaling pathways in cells of the hematopoietic lineage. BTK has been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction. |
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