Product Specification:
| Alternative Name: | HSTF1, Heat shock factor protein 1 |
| Host: | Rabbit |
| Immunogen: | Recombinant human HSF1. |
| UniProt ID: | Q00613 |
| GenBank ID: | M64673 |
| Species reactivity: | Human, Mouse, RatGerbil, Monkey, Rabbit |
| Applications: | ELISA, IP, WBEMSA |
| Recommended Dilutions/Conditions: | Western Blot (1:1,000, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects bands ~80 to ~95kDa (depending on phosphorylation status) by Western blot analysis. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol and 0.09% sodium azide. |
| Handling: | Avoid freeze/thaw cycles. |
| Shipping: | Shipped on Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | HSFs (Heat Shock family of transcription factors), which consists of HSF 1-4, bind to highly conserved Heat shock elements (HSEs) in the promoter regions of heat shock genes, ultimately regulating the expression of Heat shock proteins (Hsps). On exposure to heat shock and other stresses, HSF1 localizes within seconds to discrete nuclear granules and on recovery from stress, HSF1 rapidly dissipates from the stress granules to a diffuse nucleoplasmic distribution. |
| Technical Info/Product Notes: | ADI-SPA-901 is tested against HeLa and HeLa Heat-Shocked lysates. Upon heat shock, HSF1 is hyperphosphorylated. ADI-SPA-901 recognizes both phosphorylated and non-phosporylated HSF1 in Western Blot. |
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