ProductSpecification:

AlternativeName:	X-boxbindingprotein1,Tax-responsiveelement-bindingprotein5,TREB5,XBP2
Host:	Mouse
Immunogen:	SyntheticpeptidecorrespondingtothesequenceneartheC-terminusofhumanXBP-1,splicedisoformXBP1(S).
UniProtID:	P17861
Speciesreactivity:	Human,Mouse
Applications:	ELISA,ICC,IP,WB
RecommendedDilutions/Conditions:	Immunocytochemistry(1:100) Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication.
ApplicationNotes:	Detectsabandof~60kDabyWesternblot.
PurityDetail:	ProteinGaffinitypurified.
Formulation:	Liquid.InPBScontaining0.09%sodiumazide.
Handling:	Avoidfreeze/thawcycles.
Shipping:	ShippedonBlueIce
LongTermStorage:	-20°C
ScientificBackground:	Xboxbindingprotein1(XBP-1)isakeyproteininthemammalianunfoldedproteinresponse(UPR)thatprotectsthecellagainstthestressofmisfoldedproteinsintheendoplasmicreticulum(ER).XBP-1mRNAissplicedbyIRE1punderERstress,resultingina371aminoacidprotein(XBP-1s)whichistranslocatedtothenucleuswhereitbindstotheregulatoryelementsofdownstreamgenes.XBP-1stimulatestheproductionofERstressproteinsincludingtheERresidentproteinchaperonesgrp78andgrp94.

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